A Study of GWP42006 in People With Focal Seizures - Part A

Inclusion criteria

For inclusion in Part A of the study patients must fulfil ALL of the following criteria: * Male or female aged between 18 and 65 years, inclusive. * Well-documented history of focal epilepsy, with focal seizures as the primary seizure type, compatible electroencephalogram and clinical history. * Documented computerized tomography / magnetic resonance imaging that shows no progressive neurologic abnormality. * Has focal seizures despite prior treatment with at least two AEDs (whether as monotherapies or in combination). * Currently treated with one to three AEDs as follows: * Group 1 - subjects on inducer AEDs (and not on inhibitor AEDs) * Group 2 - subjects on inhibitor AEDs (and no on inducer AEDs) * Group 3 - subjects on AEDs that are neither inducers nor inhibitors. * All medications or interventions for epilepsy (including ketogenic diet and any neurostimulation devices for epilepsy) must have been stable for two weeks prior to screening and the patient is willing to maintain a stable regimen throughout the study. * Subject is willing to keep any factors expected to affect seizures stable (such as the level of alcohol consumption and smoking). The patient may not enter Part A of the study if ANY of the following apply: * Time of onset of epilepsy treatment is less than two years prior to enrolment. * Episode(s) of status epilepticus during one year prior to screening. * History of pseudo-seizures. * Subject has clinically significant unstable medical conditions other than epilepsy. * Subject has an illness in the four weeks prior to screening or randomization, other than epilepsy, which in the opinion of the investigator would affect seizure frequency. * Subject has significantly impaired hepatic function at Visit 1. * Active suicidal plan/intent in the past six months, or a history of suicide attempt in the last two years, or more than one lifetime suicide attempt. * Subject is currently using or has in the past used recreational or medicinal cannabis, or cannabinoid based medications within the three months prior to screening and is unwilling to abstain for the duration for the study. * Subject has taken St John's Wort in the last two weeks and/or is unwilling to abstain throughout the study. * Subject has consumed grapefruit or grapefruit juice three days prior to randomization and/or unwilling to abstain in the three days prior to Visits A2 and A4. * Any known or suspected hypersensitivity to cannabinoids, sesame oil or any of the excipients of the IMP(s). * Subjects who have received an IMP within the 12 weeks prior to the screening visit.