Heart Failure
Conditions
Keywords
frailty, Heart failure, cardiac resynchronization therapy
Brief summary
Background: The cardiac resynchronization therapy (CRT) has been shown to improve symptoms and outcome of patients with congestive heart failure (HF), and depressed left ventricular ejection fraction (LVEF \< 35 %). The rate of non-responders to CRT is estimated at 30 %. Yet, the impact of frailty on the response to CRT has not been studied, until now. Purpose : To assess the impact of frailty in the elderly, on the response to CRT.
Detailed description
Methods : Frailty is evaluated before implant ,and defined as \<14/17 points using the ONCODAGE score, in 150 patients of \> 70 years age, selected for CRT according to the ESC 2013 guidelines. The response to CRT, estimated at 9 months, is defined as an improvement of at least 5 % of the LVEF and the absence of HF hospitalization or cardiovascular death.
Interventions
OTHERFrailty
CRT device is implanted in all patients selected for the study. Frailty is evaluated before implant and defined as \<14/17 points using the ONCODAGE score
Sponsors
University Hospital, Lille
University Hospital, Rouen
University Hospital, Caen
Centre Hospitalier Universitaire, Amiens
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
70 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients of \> 70 years age, * Selected for CRT according to the ESC 2013 guidelines
Exclusion criteria
* patients included in other clinical trial which can interfere with the results of this one
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| non response on CRT | 9 months |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| seric albumin | 9 months | To assess the impact of seric albumin on the response to CRT |
| seric gammaglutamyltranferase | 9 months | To assess the impact of seric gammaglutamyltranferase on the response to CRT |
| mortality | 9 months | — |
Countries
France
Outcome results
None listed