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ColonCancerCheck Mailed Invitations: An Evaluation

ColonCancerCheck Mailed Invitations: An Evaluation

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT02364895
Enrollment
75317
Registered
2015-02-18
Start date
2013-11-30
Completion date
2014-12-31
Last updated
2015-02-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Colorectal Disorders

Keywords

Mailed invitation, Fecal Occult Blood Test, Screening

Brief summary

This study evaluates effectiveness of mailed invitations for colorectal cancer screening among screen-eligible Ontarians who are due for screening. The study will evaluate the effectiveness of mailed invitations in general (compared to no invitation) but will also determine if new invitation letters (2 letters for male, 1 letter for females) are more effective than current invitation letters used by the ColonCancerCheck program.

Detailed description

On April 1 2008, Ontario launched Canada's first organized province-wide CRC screening program, ColonCancerCheck (CCC). CCC has a dual strategy: through the primary care physician, FOBT is offered to people aged 50 to 74 years at average risk for colorectal cancer and colonoscopy to those at increased risk based on family history. In 2010-2011, approximately 30% of Ontarians 50-74 years old were screened for colorectal cancer using the FOBT. An important factor in increasing screening participation is an invitation system. A central tenet of organized screening programs is that all persons in the target population be invited to participate. In 2010, CCC began implementing a correspondence program in an effort to improve participation in colorectal cancer screening, starting with recall letters to individuals who were due for repeat screening two years after a normal fecal occult blood test (FOBT) and invitation letters to screen-eligible individuals who are due for screening and have not received correspondence from CCO to participate in colorectal cancer screening in the past two years to complete a screening test for colorectal cancer. Individuals who are due for screening includes those who have not had a FOBT in the past 2 years, a flexible sigmoidoscopy in the past 5 years, and a colonoscopy in the past 10 years. Currently, CCC sends 10,000 invitation letters monthly to 50-54 year olds only. In October 2013, the CCC correspondence program expanded to also include all eligible Ontarians 55-74 years old. The current CCC invitation letter includes general information on the benefits of screening for colorectal cancer, the screening test itself (FOBT), and contact information to get more information. It is meant to invite individuals to speak with their primary care provider about colorectal screening. In 2013 Diego Llovet, a lead qualitative researcher at CCO, completed a series of qualitative studies examining the content of current CCC correspondence materials and made recommendations to improve the content of invitation letters. These recommendations were based on four key types of information: a) findings from seven focus groups with screen-eligible Ontarians (men and women, 50-74) who provided feedback on the messages that should be included in these letters, b) input provided by six experts in health communications and health promotion on the content and style of effective cancer screening correspondence, c) evidence from behavioral science studies on barriers to participation in colorectal cancer screening, and d) theories of health behavior change. Based on findings from focus group studies examining the content of the current CCC letter, a unisex and a male-tailored invitation letter were developed. A female-tailored letter was not developed as the focus group studies with females showed that they did not prefer female tailored messaging to a unisex one. In the current study, we propose to test the effectiveness of mailed invitations for colorectal cancer screening in the real world setting of the CCC program. We will evaluate the effectiveness of mailed invitations in general (i.e., compared to no invitation) but we will also determine whether letters developed based on theories from behavioural science and on the results of qualitative studies with Ontarians in the target population are more effective than those currently used by the program. The findings from this study will be used to inform the CCC program correspondence but will also provide valuable information for the development of correspondence for other screening programs at Cancer Care Ontario and in other jurisdictions engaged in organized screening programs.

Interventions

OTHERMales control group: Deferred letter

This letter will be sent 6 months after index (mailing) date

OTHERMales Group 1: Current CCC invitation letter

This letter is currently used by the program in 50-54 year olds

OTHERMales Group 2: New letter with neutral gender content

Unisex letter

OTHERMales Group 3: New letter with male-specific content

New letter tailored for men

OTHERFemales control group: Deferred letter

This letter will be sent 6 months after index (mailing) date

OTHERFemales Group 1: Current CCC invitation letter

This letter is currently used by the program in 50-54 year olds

OTHERFemales Group 2: New letter with neutral gender content

Unisex letter

Sponsors

Cancer Care Ontario
CollaboratorOTHER
Sunnybrook Health Sciences Centre
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
FACTORIAL
Primary purpose
SCREENING
Masking
SINGLE (Investigator)

Eligibility

Sex/Gender
ALL
Age
55 Years to 74 Years
Healthy volunteers
Yes

Inclusion criteria

* 55-74 year old Ontarians with an active OHIP number

Exclusion criteria

* Death * Withdrawn from program correspondence * Prior colorectal cancer diagnosis * Any FOBT activity within the last two years, including * Flexible sigmoidoscopy within the last five years. * Colonoscopy within the last ten years * Other medical history in the last 30 months * Exclusion from screening in the last 30 months * Received a birthday letter, invitation or recall within the last two years * Inactive primary address * Missing address * Address outside Ontario

Design outcomes

Primary

MeasureTime frameDescription
fecal occult blood test (FOBT) uptake6 months after the mailing dateUsing the administrative databases at CCO, participating individuals will be followed up 6 months after the index date to measure FOBT uptake.

Secondary

MeasureTime frameDescription
FOBT or colonoscopy uptake6 monthsUsing the administrative databases at CCO, participating individuals will be followed up 6 months after the index date to measure FOBT of colonoscopy uptake.
Intermediate outcomes8-12 weeks after mailing dateWe will mail a simple questionnaire 8-12 weeks after the index date to participants in order to assess intermediate outcomes including (a) recall of letter, (b) knowledge of colorectal cancer screening, (c) intent to be screened for colorectal cancer.

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 20, 2026