Alcoholism, Attention Deficit Disorder With Hyperactivity
Conditions
Keywords
Attention Deficit Disorder with Hyperactivity, Alcohol Dependence, Adults, Treatment outcome, Mental Health
Brief summary
Some recent studies have found that adult attention deficit - hyperactivity disorder (ADHD) was frequent among patients with alcohol-dependence. However, no investigation has ever addressed whether ADHD may impact the drinking outcome. Moreover, most of the different aforementioned studies assessed ADHD using the ADHD self-report scale (ASRS). The ASRS is a screening questionnaire that is of limited diagnostic value, and the overrepresentation of high-score ASRS among patients with alcohol-dependence could be in part due to differential diagnoses such as antisocial or borderline personality disorders, executive function impairments, or isolated impulsiveness. The study aims to evaluate ADHD: Gaps between patients with Alcohol Dependence and Impact on early Relapse (AGADIR). In AGADIR, subjects with alcohol-dependence are recruited at the end of a residential detoxification program. They are assessed for ADHD using the ASRS, but also with a standardized diagnostic tool, i.e., the Diagnostic Interview for ADHD in adults (DIVA 2.0). Potential differential diagnoses are screened during the baseline visit. The patients are followed-up during the 12 first post-detox weeks, through a standardized psychosocial treatment. ASRS is re-performed at the end of the follow-up.
Interventions
BEHAVIORALcognitive and psychiatric assessment
Administered at baseline: * Clinical Institute Withdrawal Assessment for Alcohol (CIWA-Ar) * hyperactivity : Adult ADHD Self-Report Scale (ASRS), Wenders-Utah Rating Scale (WURS), Diagnostic Interview for Adult ADHD 2nd edition (DIVA 2.0) * psychiatric history : Mini International Neuropsychiatric Interview 5th edition (MINI 5.0), Personality Disorder Questionnaire for the DSM-IV (PDQ-4) * cognitive functions : Frontal Assessment Battery (FAB), Montreal Cognitive Assessment (MoCA) * impulsivity : Barratt's Impulsiveness scale 11th edition (BIS-11) * alcohol consumption: alcohol - timeline follow-back (A-TLFB) ,administered at baseline (month before hospitalization), week 4 visit, week 6 visit, and week 12 visit. * administered at week 12: ASRS
Sponsors
Institute for Scientific Research on Beverages (France)
University Hospital, Lille
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* current DSM-IV-Tr criteria for alcohol-dependence * current residential alcohol detoxification program Non-inclusion Criteria: * concurrent alcohol withdrawal symptoms, i.e., CIWA-Ar ≥ 10 * benzodiazepine diazepam-equivalent dose \> 30 mg * medical history of neurological impairment (excluding alcohol-induced cognitive disorders) * guardianship or loss of liberty * pregnant or lactating woman
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Cumulated rate of alcohol relapse | 12 weeks | Cumulated rate of alcohol relapse during the 12 weeks following the detoxification program |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Psychometric properties of the ASRS | 12 weeks | Psychometric properties of the ASRS by comparison with the DIVA 2.0 and the screening of differential diagnoses |
| Multivariate analysis of the alcohol relapse | 12 weeks | Multivariate analysis of the cumulated rate of alcohol relapse during the 12 weeks following the detoxification program |
Countries
France
Outcome results
None listed