Myocardial Infarction
Conditions
Brief summary
Detecting scarred heart muscle is important to diagnose and treat of a wide variety of heart conditions. Magnetic resonance imaging (MRI) can assess scarred heart muscle but it is time consuming, contraindicated for some patients and not tolerated by others. Computed tomography (CT) imaging has the potential to provide a rapid comprehensive assessment of the heart. This study will assess CT imaging of the heart muscle of patients who have previously undergone MRI of their heart. Using a state of the art CT scanner the investigators will develop a low radiation dose protocol to identify scarred heart muscle. The investigators will use and develop software techniques to analyse these images. This will enable us to develop a new way to identify and measure scarred heart muscle that will benefit patients with heart disease.
Interventions
RADIATIONComputed tomography late enhancement imaging
Sponsors
University of Edinburgh
Study design
Observational model
CASE_ONLY
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
40 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Presence of late enhancement on magnetic resonance imaging
Exclusion criteria
* age less than 40 * inability or unwillingness to undergo CT * renal failure (serum creatinine \>200 umol/l or estimated glomerular filtration rate \<30 ml/min) * hepatic failure * allergy to iodinated contrast * pregnancy * breast feeding * inability to undergo informed consent * fast atrial fibrillation
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Myocardial late enhancement | Immediate | The amount of myocardial late enhancement measured on computed tomography as compared to magnetic resonance imaging. |
Outcome results
None listed