Infection, Starvation
Conditions
Keywords
Hepatitis B virus, Metabolovirus
Brief summary
Hepatitis B virus is a small DNA virus that affects 400 million people worldwide. The virus infects the liver and previous studies, done in tissue culture and in animals, have shown that viral replication is affected by metabolic changes occurring in the liver. Specifically, starvation induces HBV gene expression and replication, in parallel to the activation of the gluconeogenesis response, and feeding attenuates viral activity. In this study we are going to recruit HBV patients with detectable viremia and analyze their viral load after an over night starvation versus after a morning meal. Our hypothesis is that following an over-night starvation viral load will be higher than that in the fed state.
Interventions
BEHAVIORALOver night starvation (fasting)
HBV viral load will be analyzed after over-night starvation versus following a morning meal
Sponsors
Rabin Medical Center
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* Hepatitis B virus patients with detectable viremia * \>18 years old * signed a consent form
Exclusion criteria
* patients with malignancy * Patients with diabetes mellitus * Alcohol consumption of more than 140grams a week * Advanced liver disease * HCV or HIV infection * Pregnancy * Mental retardation or unable to understand basic explanation about the study -
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| A change in the levels of hepatitis B viremia (HBV viral load) between starvation and fed states | Following an over-night (8-12hours) starvation versus following a morning meal. 6 visits overall, one visit every 2 weeks (12 weeks over all). |
Contacts
Primary ContactAmir Shlomai, MD/PhD
Backup ContactShulamit Greenstein, PhD
Outcome results
None listed