Metabolic Exercise Testing

Exercise Testing in Metabolic Myopathies

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02362685

Acronym

RANNOU

Enrollment

1000

Registered

2015-02-13

Start date

2008-09-30

Completion date

2027-12-31

Last updated

2020-01-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Exercise Test, Metabolic Myopathies, Myalgia

Keywords

Metabolic myopathies, Exercise testing, Blood sample, Muscle biopsy, Genetic analysis, Cycloergometer, Grip-test, Exercise physiology, Muscle physiology

Brief summary

Exertional symptoms are the hallmarks of metabolic myopathies, supporting the concept of using functional tests when this diagnosis is suspected. Exercise increases the concentration of muscle metabolites in the venous blood supply (e.g. lactate, pyruvate, and ammonia) especially during recovery. The purpose of this study is to compare the results of exercise testing with to the data from muscle biopsy or genetic analysis.

Interventions

DEVICEfunctional test

subjects perform a metabolic exercise testing

GENETICmatching genotype with phenotype

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

5 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Referred to the Physiology Department of Brest Hospital for a metabolic exercise test * Ability to provide informed consent

Exclusion criteria

* Contraindication(s) to perform cardiopulmonary exercise testing (ATS/ACCP statement on cardiopulmonary exercise testing, Am J respi Care Med 167: 211-77, 2003) * Pregnancy or unknown pregnancy status.

Design outcomes

Primary

Measure	Time frame	Description
Whole-body dynamic exercise	Participants will be followed for an expected average of 1 year to determine whether a muscle biopsy is performed	The relation between Cardiopulmonary exercise test variables and the results of muscle biopsy or genetic analysis will be evaluated.
Grip-test	Participants will be followed for an expected average of 1 year to determine whether a muscle biopsy is performed	The relation between Grip-test variables and the results of muscle biopsy or genetic analysis will be evaluated.
Blood tests	Participants will be followed for an expected average of 1 year to determine whether a muscle biopsy is performed	The results of blood analysis from samples performed before, during, and after exercise will be compared to the results of muscle biopsy or genetic analysis.

Countries

France

Contacts

Primary ContactFabrice Rannou, MD, PhD

fabrice.rannou@chu-brest.fr33(0)298347366

Backup ContactFabrice Rannou, MD, PhD

fabrice.rannou@univ-brest.fr33(0)298347366

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026