The Effect of Vitamin D on in Vitro Fertilization Outcome

The Effect of Vitamin D on in Vitro Fertilization Outcome, a Prospective Observational Study

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02361827

Enrollment

688

Registered

2015-02-12

Start date

2018-01-01

Completion date

2024-12-01

Last updated

2026-05-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

in Vitro Fertilization, Ongoing Pregnancy Rate, Vitamin D

Keywords

Vitamin D, IVF outcome

Brief summary

To date, several studies have been done to explore the relationship between Vitamin D level and IVF outcome; however, the results are controversial. Sample sizes in these studies mentioned above were relatively small. In addition, there are no prospective cohort studies in this field. Thus, here the investigators carry this prospective observational cohort study to demonstrate the relationship between vitamin D level and IVF outcome.

Detailed description

Vitamin D level is measured before the commence of IVF cycle. According to Vitamin D level, patients are divided into 3 groups: A, Deficient, \<20 ng/mL; B, Insufficient, 20-29.9 ng/mL; C, Replete, \>30 ng/mL. Ongoing pregnancy rate are compared among these three groups after controlling age, number of embryos transferred, ect. In addition, Vitamin D level is also meassured before embryo transfer in FET cycles with PGT treatment. The effect of Vitamin D on IVF outcome is detected in patients transferred with Euploid embryos.

Interventions

PROCEDUREEmbryo transfer

For patients in each group after oocyte retrieval, they will have embryo transferred 3 or 5 days after oocyte retrieval. For FET cycles, they will have ET with an euploid blastocyst.

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

FEMALE

Age

21 Years to 40 Years

Healthy volunteers

Inclusion criteria

1. age between 21-40 years old 2. basal FSH hormone level less than 10 mIU/mL 3. the first cycle of IVF treatment with standard long protocol 4. both ovarian present and normal uterus.

Exclusion criteria

1. Important data missing 2. Gametes donation cycles 3. Anyone that does not meet the inclusion criteria

Design outcomes

Primary

Measure	Time frame	Description
Ongoing pregnancy rate	12 weeks after embryo transfer	12 weeks after embryo transfer, gestational sac with fetal heart present inside uterus

Secondary

Measure	Time frame	Description
Ectopic pregnancy rate	35 days after embryo transfer	Ectopic pregnancy is defined as serum HCG positive, yet with no gestational sac present inside uterine cavity

Countries

China

Contacts

PRINCIPAL_INVESTIGATORZhiqin Bu, MD, PhD

Reproductive Medical Center, First Affiliated Hospital of Zhengzhou University

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: May 28, 2026