Serum Vitamin D Levels and Pregnancy Rates in Women Undergoing Elective Frozen Embryo Transfer (eFET)

Comparing the Serum Vitamin D Levels and Pregnancy Rates in Women Undergoing Elective Frozen Embryo Transfer (eFET)

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02361710

Enrollment

200

Registered

2015-02-12

Start date

2015-04-30

Completion date

2016-07-31

Last updated

2016-01-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pregnancy

Keywords

Vitamin D, pregnancy rate, eFET

Brief summary

The aim of this study is determining the affects of serum vitamin D levels to implantation and clinical pregnancy rates in women undergoing elective vitrified/thawed embryo transfer. Two groups will be identified according to the serum vitamin D levels on eFET transfer day and later on implantation, clinical pregnancy and ongoing pregnancy rates will be compared between those groups

Detailed description

In the last decade there have been growing evidence about Vitamin D receptors and their role in female genital tract. But these studies are yet not well designed and the results should be interpreted cautiously. Although some of these studies advocating the Vitamin D deficiency as an negative circumstance on pregnancy rates some of the others don't agree. According to contradictory results understanding the actual role of those receptors needs more observation. Latest retrospective analyse postulated that, vitamin D deficiency in fresh single embryo transfer cycles may reduce pregnancy rates mediated by endometrium or ovarian reserve and stimulation characteristics. For this reason the investigators aimed to explore the effect of serum Vitamin D levels on pregnancy rates in infertile population undergoing frozen embryo transfer.

Interventions

PROCEDUREfrozen embryo transfer

comparison of groups according to their serum vitamin D levels on frozen embryo transfer day

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 35 Years

Healthy volunteers

Inclusion criteria

* 18 years to 35 years age, a frozen ET with 1 Day 5 (blastocyst stage) embryo * Infertile women undergoing ICSI (intracytoplasmic sperm injection) cycle * Factors affecting fertility are Tubal * Unexplained or ovulatory disturbances,

Exclusion criteria

* Need to do Preimplantation Genetic Diagnosis * Presence of endometriosis and adenomyosis * Severe male factor infertility

Design outcomes

Primary

Measure	Time frame	Description
clinical pregnancy rate	4 weeks after embryo transfer	The presence of intrauterine gestational sac at 7 weeks of gestation

Secondary

Measure	Time frame	Description
implantation rates	3 weeks after embryo transfer	number of gestational sacs per transferred embryo.
ongoing pregnancy rates	18 weeks after embryo transfer	Pregnancy that had completed ≥20 weeks of gestation

Countries

Turkey (Türkiye)

Contacts

Primary Contactcem celik

cemcel@yahoo.com+905324205365

Backup Contactkubra n boynukalin

kboynukalin@gmail.com+905336412040

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026