the PEEP Setting of ARDS
Conditions
Brief summary
The investigators conducted a pilot study to compare the effect of Positive End Expiratory Pressure(PEEP) setting guide by lung electrical impedance tomography(EIT) and ARDS-net PEEP-FiO2 table on survival in subjects with mild/severe Acute Respiratory Distress Syndrome(ARDS).
Interventions
OTHERthe EIT guide the individualized PEEP Setting
the EIT guide the individualized PEEP Setting in the EIT group
Sponsors
Peking Union Medical College Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
Inclusion: 1. acute respiratory distress syndrome with ratio of partial pressure of arterial oxygen over fraction of inspired oxygen (PaO2:FiO2)\<300 and PEEP \>5cmH2O 2. Body mass index \< =40 3. Written inform consent Exclusion: 1. pregnant，intracranial hypertension 2. left ventricular dysfunction (EF\<25% ) 3. Patients with end-stage conditions(death expected within 90 days)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| survival | 28-day | Non-survive and survive |
| Arterial oxygenation | 72h | PaO2(mmHg) measured by blood gas analysis |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| length of ICU stay and mechanical ventilated day | 28days | Days of ICU stay and received mechanical ventilation(day) |
| pneumothorax requiring chest tube during first 7 days; barotrauma during first 7 days; | 7days | new-onset of pneumothorax and barotrauma |
Countries
China
Outcome results
None listed