Kefir on Bone Mineral Density and Bone Metabolism in Osteoporotic Patients

Short-term Effect of Kefir-fermented Milk Consumption on Bone Mineral Density and Bone Metabolism in Osteoporotic Patients

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02361372

Enrollment

Registered

2015-02-11

Start date

2010-05-31

Completion date

2012-01-31

Last updated

2015-09-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Osteoporosis

Brief summary

In a controlled, parallel, double-blind intervention study over 6 months, the investigators investigated the effects of kefir-fermented milk (1,600 mg/kg) supplemented with calcium bicarbonate (CaCO3, 1,500 mg/kg) and bone metabolism in 40 osteoporosis patients, and compared them with CaCO3 alone without kefir supplements. Bone turnover markers were measured in fasting blood samples collected before therapy and at 1, 3, and 6 months. BMD values at the spine, total hip, and hip femoral neck were assessed by dual-energy x-ray absorptiometry (DXA) at baseline and at 6 months.

Interventions

OTHERPlacebo

Placebo daily for 6 months

OTHERCaCO3

CaCO3 daily for 6 months

OTHERKefir

Kefir daily for 6 months

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

ALL

Age

55 Years to 70 Years

Healthy volunteers

Yes

Inclusion criteria

* Clinical diagnosis of osteoporosis patients

Exclusion criteria

* Any previous use of parathyroid hormone or sodium fluoride, use of anabolic steroids or growth hormone within 6 months before trial entry or oral or intravenous systemic corticosteroids within 12 months, and any previous use of strontium.

Design outcomes

Primary

Measure	Time frame
bone mineral density and bone regeneration	3 months

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 3, 2026