Role of Oxytocin in Telling and Detecting Lies

Status

Withdrawn

Phases

Early Phase 1

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02361177

Enrollment

Registered

2015-02-11

Start date

2016-01-31

Completion date

2016-04-30

Last updated

2016-06-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dyssocial Behavior

Brief summary

The investigators are interested in the impact of intranasal oxytocin in unethical behavior.

Detailed description

The objective of this project is to further explore the role of oxytocin in moral judgment and ethical behavior. Oxytocin is a peptide hormone produced in a variety of hypothalamic neurons. It is released into the brain or brought into general circulation through sensory stimuli in a pulsatile fashion. In social psychology research, oxytocin is hypothesized to coordinate both the causes and effects of positive social interactions in a biofeedback loop.

Interventions

DRUGOxytocin

Intranasal oxytocin is hypothesized to amplify the influence of social norms on unethical behavior.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

BASIC_SCIENCE

Masking

TRIPLE (Subject, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

MALE

Age

18 Years to 30 Years

Healthy volunteers

Yes

Inclusion criteria

* Male

Exclusion criteria

* \_\_\_\_\_ \_\_\_\_\_BP \> 130/85, HRT \> 95 (can be included at discretion of study physician/designee) * \_\_\_\_\_History of seizures * \_\_\_\_\_Neurological Disorder * \_\_\_\_\_Current psychiatric disorder * \_\_\_\_\_Previous psychiatric disorder (can be included at discretion of PI) * Date last episode (if \> 1 year, include; if \<1 year, at discretion of PI) * \_\_\_\_\_Current use of psychoactive drugs * \_\_\_\_\_Previous use of psychoactive drugs (can be included at discretion of PI) \_\_\_\_\_Date last medicated\_\_\_\_\_ \_\_\_\_\_Type of medication\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_ * \_\_\_\_\_Current use of anticoagulants * \_\_\_\_\_Current use of corticosteroids * \_\_\_\_\_Previous head trauma (can be included at discretion of PI) * \_\_\_\_\_Alcoholism or substance abuse * \_\_\_\_\_Carcinoma of the breast or prostate * \_\_\_\_\_Renal or Hepatic diseases * \_\_\_\_\_Chronic lung diseases * \_\_\_\_\_Cancer * \_\_\_\_\_Liver problems * \_\_\_\_\_Hypertension/Cardiac diseases * \_\_\_\_\_Cardiovascular Disease * \_\_\_\_\_Nephritis * \_\_\_\_\_Diabetes (use of insulin) /Obesity * \_\_\_\_\_Endocrine disease or malignancy * \_\_\_\_\_Asthma (can be included as discretion of study physician/designee, if episodes are infrequent, nonmedicated, and no active problems at time of study) * Medication * Frequency of episodes\_\_\_\_ \_\_\_\_\_Date of last episode\_\_\_\_\_ * \_\_\_\_\_Migraines(can be included as discretion of study physician/designee, if episodes are infrequent, nonmedicated, and no active problems at time of study) * Medication \_\_\_\_\_Frequency of migraines\_\_\_\_\_ \_\_\_\_\_Date of last migraine\_\_\_\_\_ * \_\_\_\_\_High levels of physical contact with women or children

Design outcomes

Primary

Measure	Time frame	Description
Unethical behavior	130 minutes	To measure unethical behavior, we will calculate whether participants took more money than they actually earned on a problem-solving task.

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026