Asthma, Hypersensitivity, Inflammation, Rhinitis
Conditions
Keywords
child, allergic rhinitis, asthma, nitric oxide, bronchial hyper-responsiveness
Brief summary
This is a prospective observational study , to clarity the characteristics of airway inflammation, airway reactivity and airway resistance in rhinitic children with or without asthma and to explore the possible predictors in the progression of allergic rhinitis to asthma.
Detailed description
Children 6-15 years old with allergic rhinitis and/or asthma diagnosed by specialist physician are enrolled in the department of respiratory and otorhinolaryngology and pediatrics in Guangzhou Institute of Respiratory Disease. According to presence of typical symptoms and signs, patients are divided into allergic rhinitis without asthma (AR group) , allergic rhinitis concomitant asthma (AS+AR group), asthma without rhinitis (AS group). In addition, healthy students in a school are enrolled as normal control group. History of all subjects are collected, the following measurements are performed: skin prick test (SPT), peripheral blood cells five-classification test, serum total immunoglobulin E (IgE) and specific IgE of common inhalant allergens testing, nasal lavage and induced sputum cells classification ，pulmonary function test, bronchial provocation test using methacholine，airway resistance measured by impulse oscillation technique, the levels of eosinophil（ECP），eosinophil peroxidase（EPO）.Meanwhile myeloperoxidase （MPO）and eosinophil-derived neurotoxin (EDN) are measured in induced sputum ,in nasal lavage and in serum.
Interventions
None listed
Sponsors
Guangzhou Institute of Respiratory Disease
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
6 Years to 15 Years
Healthy volunteers
Yes
Inclusion criteria
* Clinical diagnosis of allergic rhinitis and/or asthma * Sensitized to more than 1 common aeroallergens
Exclusion criteria
* Respiratory infection 2 weeks prior to initial visit * Children with nasal polyposis * History of immunotherapy * Unable to complete the test or had limited understanding * Use of systemic corticosteroids 4 weeks prior to initial visit * Nasal and inhaled corticosteroids 2 weeks prior to initial visit * Leukotriene receptor antagonists 2 weeks prior to initial visit
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To explore if an elevated level of fractional exhaled nitric oxide(FeNO) is a possible predictor of bronchial hyperresponsiveness in AR. | 1 year |
Secondary
| Measure | Time frame |
|---|---|
| To compare levels of eosinophil（ECP），eosinophil peroxidase（EPO）, myeloperoxidase （MPO）and eosinophil-derived neurotoxin (EDN) in induced sputum and nasal lavage fluid among the groups. | 1 year |
| To explore if an elevated eosinophils in induced sputum is a possible predictor of bronchial hyperresponsiveness in AR. | 1 year |
| To compare forced vital capacity (FVC) , forced expiratory volume in 1 second (FEV1)， forced expired flow at 25% of FVC(FEF25) and forced expired flow at 75% of FVC (FEF75) among groups. | 1 year |
| To compare lower airway resistance (Z5,R5,X5,R5-20,R20 and Fres) using impulse oscillation among the groups [Allergic rhinitis(AR) group, Asthma group, AR+Asthma and control group]. | 1 year |
| To compare cumulative dosage of methacholine causing a 20% fall in forced expiratory volume in 1 second (PC20FEV1-MCH) among the groups. | 1 year |
| To explore if an elevated eosinophils in nasal nasal lavage fluid is a possible predictor of bronchial hyperresponsiveness in AR. | 1 year |
Countries
China
Outcome results
None listed