Chest Pain
Conditions
Keywords
Magnetocardiography, Myocardial Infarction, Non-ischaemic chest pain
Brief summary
The purpose of this pilot research study is to identify the characteristics of magnetocardiograms that correlate with a non ischemic chest pain status and a myocardial infarction patient status. The study uses a non SQUID magnetocardiogram device.
Detailed description
Magnetocardiography (MCG) is a passive, non-contact technique to measure the electromagnetic activity of the heart. Heart muscle is controlled by electrical impulses that initiate contraction of the myocardium to pump blood around the body. A wave of depolarisation and repolarisation helps to coordinate the heart's activity which is usually measured using an electrocardiogram (ECG) which reflects the surface electrical manifestation of myocardial depolarisation and repolarisation For every electrical signal there is a corresponding magnetic field, as defined by Faraday's law of induction, and it is this magnetic field that MCG measures. There are two key advantages of looking at the magnetic field rather than the electrical signal. (1) The signal is not attenuated as it passes through the body, so information is not lost and (2) changes in the action potential (for example those caused by ischemia) are 'magnified' in the magnetic field so are easier to detect by sensors that are not in direct contact with the body. SQUID MCG has been used widely in cardiology research, and previous clinical studies have shown that the technology has potential for the analysis of patients with coronary artery disease. The aim of this pilot study is to identify characteristics of MCG that differentiate patients with non-ischaemic chest pain from those with a myocardial infarction. .
Interventions
None listed
Sponsors
Quantum Imaging Limited
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Non ischemic chest pain subject inclusion criteria * Subjects will be males or females over the age of 18. * Subjects will have experienced chest pain within the last 8 weeks and have been subsequently referred to the rapid access chest pain clinic (RACPC). * Subjects will have no coronary artery disease/ischemia as demonstrated by one of the following: MRI, myoview or stress echo within no less than 4 weeks prior to the magnetocardiogram (MCG) scan. * Subjects will have given written informed consent to participate in the study. Myocardial Infarction subject inclusion criteria * Subjects will be males or females over the age of 18. * Subjects will have experienced chest pain and have been admitted to the cardiology unit. * Subjects will have an abnormal level of Troponin (≥50ng/l) taken at 12 hours following the onset of chest pain. * Subjects will be suitable to have an MCG scan taken within 48 hours of the onset of chest pain and prior to coronary angioplasty or any other surgical intervention. * Subjects will have given written informed consent to participate in the study.
Exclusion criteria
Non ischemic chest pain subject
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Magnetocardiogram Characteristics in patients with chest pain | 1 hour | Quantitative comparison of magnetocardiogram characteristics of non ischaemic chest pain patients compared to those with an acute myocardial infarction |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Device Safety | At time of scan for all patiients (Varies) | Any adverse effects, adverse device effects, Unanticipated serious device effects |
Countries
United Kingdom
Outcome results
None listed