Healthy
Conditions
Keywords
quantitative sensory testing, contact heat evoked potentials, vection stimulation, 3D-turntable, Volunteers
Brief summary
The goal is to establish the practical usefulness of vestibular stimulation for modulating pain perception and to describe the possible mechanisms that could underlie neural vestibular-somatosensory interactions.
Interventions
PROCEDURE3D Turntable
PROCEDUREVection stimulation
PROCEDUREQuantitative sensory testing
Measurement of warm and cold detection and pain thresholds
PROCEDURECHEPS
Measurement of amplitude and latency of cortically evoked potentials
Sponsors
University of Zurich
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
MALE
Age
18 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* Weight: 50 - 100 kg * Height: 155 - 185 cm * Male subjects 18 years to 60 years of age * Sufficient command of German language * Written informed consent by the participant after information about the project * Without any known history of neurological disease (especially motor, somatosensory disorders, peripheral neuropathies). * Right-handedness
Exclusion criteria
1. Intellectually or mental impaired subjects 2. Drug abuse 3. Chronic alcohol consumption 4. No use of marihuana 24h before measurements. 5. No history of vestibular or auditory disorders. 6. Diabetes mellitus 7. Participants of other studies during study period and 30 days prior to study begin 8. Any regular concomitant medication 9. Abnormal QST parameters at the baseline measurement. 10. Absent CHEPs-Potentials at the baseline measurement.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Pain thresholds | After study inclusion, Day1 | The change in heat or cold pain threshold after physical vestibular stimulation and vection stimulation |
Countries
Switzerland
Outcome results
None listed