Periodontitis
Conditions
Keywords
neopterin, plasma, urine, saliva, menopause, periodontitis
Brief summary
Neopterin has been identified as a marker of cellular immune system activation. It is synthesized by macrophages upon stimulation with the cytokine interferon-gamma and is indicative of a pro-inflammatory immune status. Neopterin concentration increases with increasing severity of periodontal disease in diverse body fluids like Urine, Saliva and Plasma. Hence Neopterin can be considered as an important inflammatory marker in periodontal disease as well as other systemic diseases.
Detailed description
At baseline - plasma, urine and saliva samples were collected and analysed for neopterin levels from the pre and post-menopausal women with periodontitis . Followed by scaling and root planing done in both the groups. After 3 months again these 3 samples were collected and analysed for post treatment neopterin levels
Interventions
PROCEDURENon surgical periodontal therapy
scaling and root planing
Sponsors
Panineeya Mahavidyalaya Institute of Dental Sciences & Research Centre
Study design
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
FEMALE
Age
40 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* moderate to chronic periodontitis * non-smokers * minimum 15 natural teeth present
Exclusion criteria
* patients on long term steroid medication * with gross oral pathology or tumors * undergoing hormone replacement therapy * not undergone periodontal therapy in past 6 months * under medication in past 6 months * systemic disorders and drugs which influence the periodontium
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Co-relating neopterin and periodontitis levels in pre and post menopausal women | 3 months |
Outcome results
None listed