Postoperative Nausea and Vomiting
Conditions
Keywords
nausea, postoperative, postoperative nausea, postoperative vomiting, vomiting, postoperative
Brief summary
The purpose of this study is to determine whether patients at high risk for postoperative nausea and vomiting can benefit from aprepitant, ondansetron and dexamethasone in the perioperative period.
Detailed description
High risk surgical patients for PONV, scheduled for laparoscopic surgery will be distributed in two groups: Group I will receive aprepitant 80 mg per os and Group II will receive placebo per os, one hour before surgery. In the operating room, patients will be submitted to combined intravenous general anesthesia plus spinal anesthesia. All patients will receive dexamethasone 4 mg and ondansetron 4 mg intravenously during the surgical procedure. After surgery, patients will be monitored for pain, nausea and vomiting during 24 hours.
Interventions
DRUGAprepitant
Aprepitant or placebo will be administered to the patient before surgery
Sponsors
Instituto do Cancer do Estado de São Paulo
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Caregiver)
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* high risk patients for nausea and vomiting
Exclusion criteria
* cardiovascular disease, or hypersensibility to any of the drugs involved in the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of nausea and vomiting in postoperative period | 24 hours |
Countries
Brazil
Outcome results
None listed