Ketone Body Metabolism, Brain Metabolism
Conditions
Brief summary
This project tend to investigate the affection of ketone bodies on brain metabolism. This will be done by measuring human cerebral uptake of energy substrates, together with functional parameters, using PET imaging and appropriate radiotracers under hyperketonemia in healthy subjects by ketone infusion. Hypotheses 1. Increased levels of ketone bodies in healthy subjects leads to decreased glucose uptake by brain cells contributing to hyperglycaemia. 2. Increased levels of ketone bodies in healthy subjects leads to increased cerebral blood flow. 3. Altered oxygen consumption during hyperketonemia in healthy subjects.
Interventions
DRUGketone
3-OHB is infused intravenously.
DRUGplacebo
Saline infusion.
Sponsors
University of Aarhus
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
50 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy * BMI 20-30 kg/m2
Exclusion criteria
* smoking * alcohol abuse * severe comorbidity * blood donation 6 month prior * claustrophobia
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Glucose metabolism in brain, CMR | t=240-360 minutes | cerebral glucose metabolism measured by PET tracer during the above time frame |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Stress metabolism | 0-360 minutes | growth hormone, cortisol, glucagon, adrenalin, ghrelin. |
| Oxygen use | T=150-200 minutes | cerebral oxygen consumption measured by PET tracer during the above time frame |
| cerebral blood flow | t=180-250 minutes | cerebral blood flow measured by PET tracer during the above time frame |
| Intramuscular signaling | t= 260 minutes | protein and insulin signaling in muscle |
Countries
Denmark
Outcome results
None listed