Genetics of Uveitis

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02357238

Enrollment

1500

Registered

2015-02-06

Start date

2011-01-01

Completion date

2030-01-01

Last updated

2026-03-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infectious Uveitis, Uveitis

Keywords

Uveitis, Infectious

Brief summary

In order to improve the investigators knowledge about uveitis and the underlying mechanism of disease, the investigators propose collecting blood from patients with uveitis, isolating DNA and sequencing the DNA to identify genetic mutations or associations in these patients.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

6 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Any patient above with the diagnosis of uveitis. * Any patient with a diagnosis of infectious uveitis such as toxoplasmosis retinochoroiditis, herpes associated retinitis.

Exclusion criteria

* Patients who are unable to give consent * Patients in whom an adequated blood sample can not be obtained.

Design outcomes

Primary

Measure	Time frame	Description
Non infectious uveitis	5 years	Distinct uveitis conditions will have a polymorphism association or specific mutation.

Secondary

Measure	Time frame	Description
Infectious uveitis	5 years	Infectious uveitis (such as herpes associated uveitis, toxoplasmosis retinochoroiditis) will have specific polymorphisms/mutations in innate immune system genes which predispose the patient to infectious uveitis.

Countries

United States

Contacts

CONTACTKimberly M Baynes, BSN, RN, COA

baynesk@ccf.org216-444-2566

PRINCIPAL_INVESTIGATORSunil K. Srivastava, M.D.

The Cleveland Clinic

Outcome results