Biomarkers in Acute Cardiac Care

Conditions

Acute Coronary Syndrome, Chest Pain, Myocardial Infarction

Keywords

troponin, myocardial infarction, acs, AMI, biomarker, BACC, high-sensitivity

Brief summary

The primary aim of the study is to investigate new cardiac biomarkers and algorithms to diagnose acute coronary syndrome in patients with suspected acute myocardial infarction.

Detailed description

The primary aim of the study is to detect and evaluate new cardiac biomarkers, evaluate and improve acute coronary syndrome (ACS) risk scores, which takes into account clinical, gender specific, psycho-social and lifestyle-risk factors, protein patterns and genetic variability in addition to the classical risk factors with respect to the primary endpoint of acute myocardial infarction. Secondary study aims are : * To provide estimates for the incidence of ACS in patients presenting with recent onset chest pain; * To provide accurate, quantifiable measures of precursors of ACS; * DNA, RNA, cells, and serum/plasma for comprehensive genetic, gene expression and proteomic studies * To explore the impact of ACS candidate genes on cardiovascular risk stratification by using genome-wide analyses and a biological systems approach; * To explore proteins relevant for ACS; * To allow the identification of new therapeutic targets; * To evaluate the impact of socio-economic factors on ACS and CAD risk. Patients will be followed up during the hospital stay. Afterwards a telephone follow-up will take place after 30 days, 6, 24 and 48 months.

Völschow B, Strauß B, Sörensen NA, Thießen N, Lehmacher J, Toprak B, Abdennadher B, Dehkordi F, Haller PM, Scharlemann L, Schock A, Petersmann A, Gauß F, Twerenbold R, Neumann JT.

2026-04-20

10.1093/ehjacc/zuag044

Bedside echocardiography in patients with suspected acute myocardial infarction without ST elevation

Paul M. Haller, Alina Schock, Caroline Kellner, Jonas Lehmacher, Betül Toprak et al. (14 authors)

Clinical Research in Cardiology2025-08-19

10.1007/s00392-025-02724-2

Identification of patients with suspected NSTE-ACS in the observe zone: evaluating GRACE 1.0 score and a biomarker panel for risk stratification and management optimization

Mustafa Yı́ldı́rı́m, Christoph Reich, Christian Salbach, Moritz Biener, Matthias Mueller‐Hennessen et al. (12 authors)

Clinical Research in Cardiology2025-04-142 citations

10.1007/s00392-025-02642-3

A Common Algorithm for Cardiac Troponin to Rule Out and Rule in Acute Myocardial Infarction.

Thieβen N, Pickering JW, Kellner C, Haller PM, Lehmacher J, Toprak B, Twerenbold R, Sörensen NA, Pemberton C, Troughton R, Richards AM, Sharif S, Worster A, Than M, Kavsak PA, Neumann JT.

2025-02-263 citations

10.1016/j.cjca.2025.02.029

Long-term outcome of patients presenting with myocardial injury or myocardial infarction

Paul M. Haller, Caroline Kellner, Nils A. Sörensen, Jonas Lehmacher, Betül Toprak et al. (11 authors)

Clinical Research in Cardiology2023-11-208 citations

10.1007/s00392-023-02334-w

Rising and Falling High‐Sensitivity Cardiac Troponin in Diagnostic Algorithms for Patients With Suspected Myocardial Infarction

Paul M. Haller, Nils A. Sörensen, Tau Hartikainen, Alina Goßling, Jonas Lehmacher et al. (16 authors)

Journal of the American Heart Association2023-05-096 citations

10.1161/jaha.122.027166

Personalized diagnosis in suspected myocardial infarction.

Neumann JT, Twerenbold R, Ojeda F, Aldous SJ, Allen BR, Apple FS, Babel H, Christenson RH, Cullen L, Di Carluccio E, Doudesis D, Ekelund U, Giannitsis E, Greenslade J, Inoue K, Jernberg T, Kavsak P, Keller T, Lee KK, Lindahl B, Lorenz T, Mahler SA, Mills NL, Mokhtari A, Parsonage W, Pickering JW, Pemberton CJ, Reich C, Richards AM, Sandoval Y, Than MP, Toprak B, Troughton RW, Worster A, Zeller T, Ziegler A, Blankenberg S, ARTEMIS study group.

2023-05-0220 citations

10.1007/s00392-023-02206-3

Diagnostic performance of a device for acoustic heart sound analysis in patients with suspected myocardial infarction

Jonas Lehmacher, Franz‐Josef Neumann, Nils A. Sörensen, Alina Goßling, Samuel Emil Schmidt et al. (9 authors)

Open Heart2023-03-013 citations

10.1136/openhrt-2022-002090

Prognostic Implications of a Second Peak of High-Sensitivity Troponin T After Myocardial Infarction

Tau Hartikainen, Alina Goßling, Nils A. Sörensen, Jonas Lehmacher, Franz‐Josef Neumann et al. (7 authors)

Frontiers in Cardiovascular Medicine2022-01-318 citations

10.3389/fcvm.2021.780198

A Biomarker Model to Distinguish Types of Myocardial Infarction and Injury.

Neumann JT, Weimann J, Sörensen NA, Hartikainen TS, Haller PM, Lehmacher J, Brocks C, Tenhaeff S, Karakas M, Renné T, Blankenberg S, Zeller T, Westermann D.

2021-08-0133 citations

10.1016/j.jacc.2021.06.027

The association of anaemia and high-sensitivity cardiac troponin and its effect on diagnosing myocardial infarction

Paul M. Haller, Franz‐Josef Neumann, Nils A. Sörensen, Tau Hartikainen, Alina Goßling et al. (10 authors)

European Heart Journal Acute Cardiovascular Care2021-07-2112 citations

10.1093/ehjacc/zuab066

Diagnostic Validation of a High-Sensitivity Cardiac Troponin I Assay

Nils A. Sörensen, Alina Goßling, Franz‐Josef Neumann, Tau Hartikainen, Paul M. Haller et al. (13 authors)

Clinical Chemistry2021-04-3019 citations

10.1093/clinchem/hvab070

Differences in measurement of high-sensitivity troponin in an on-demand and batch-wise setting

Nils A. Sörensen, Franz‐Josef Neumann, Francisco Ojeda, Thomas Renné, Mahir Karakas et al. (8 authors)

European Heart Journal Acute Cardiovascular Care2020-07-237 citations

10.1177/2048872620924198

Application of A Machine Learning-Driven, Multibiomarker Panel for Prediction of Incident Cardiovascular Events in Patients with Suspected Myocardial Infarction

Franz‐Josef Neumann, Nils A. Sörensen, Tanja Zeller, Craig A. Magaret, Grady Barnes et al. (14 authors)

Biomarkers in Medicine2020-05-286 citations

10.2217/bmm-2019-0584

Application of High-Sensitivity Troponin in Suspected Myocardial Infarction

Franz‐Josef Neumann, Raphael Twerenbold, Francisco Ojeda, Nils A. Sörensen, Andrew R. Chapman et al. (54 authors)

New England Journal of Medicine2019-06-26333 citations

10.1056/nejmoa1803377

Predictive value of soluble urokinase-type plasminogen activator receptor for mortality in patients with suspected myocardial infarction.

Sörensen NA, Nikorowitsch J, Neumann JT, Rübsamen N, Goßling A, Hartikainen TS, Blankenberg S, Westermann D, Zeller T, Karakas M.

2019-04-1615 citations

10.1007/s00392-019-01475-1

Evaluation of a new ultra-sensitivity troponin I assay in patients with suspected myocardial infarction.

Neumann JT, Sörensen NA, Rübsamen N, Ojeda F, Schock A, Seddighizadeh P, Zeller T, Westermann D, Blankenberg S.

2018-12-0520 citations

10.1016/j.ijcard.2018.12.001

Clinical chemistry score versus high-sensitivity cardiac troponin I and T tests alone to identify patients at low or high risk for myocardial infarction or death at presentation to the emergency department

Peter A. Kavsak, Franz‐Josef Neumann, Louise Cullen, Martin Than, Colleen Shortt et al. (25 authors)

Canadian Medical Association Journal2018-08-1945 citations

10.1503/cmaj.180144

Impact of age on the performance of the ESC 0/1h-algorithms for early diagnosis of myocardial infarction

Jasper Boeddinghaus, Thomas Nestelberger, Raphael Twerenbold, Franz‐Josef Neumann, Bertil Lindahl et al. (74 authors)

European Heart Journal2018-08-05120 citations

10.1093/eurheartj/ehy514

Prospective Validation of the 0/1-h Algorithm for Early Diagnosis of Myocardial Infarction.

Twerenbold R, Neumann JT, Sörensen NA, Ojeda F, Karakas M, Boeddinghaus J, Nestelberger T, Badertscher P, Rubini Giménez M, Puelacher C, Wildi K, Kozhuharov N, Breitenbuecher D, Biskup E, du Fay de Lavallaz J, Flores D, Wussler D, Miró Ò, Martín Sánchez FJ, Morawiec B, Parenica J, Geigy N, Keller DI, Zeller T, Reichlin T, Blankenberg S, Westermann D, Mueller C.

2018-08-01141 citations

10.1016/j.jacc.2018.05.040

Relations of Sex to Diagnosis and Outcomes in Acute Coronary Syndrome

Nils A. Sörensen, Franz‐Josef Neumann, Francisco Ojeda, Sarina Schäfer, Christina Magnussen et al. (13 authors)

Journal of the American Heart Association2018-03-1041 citations

10.1161/jaha.117.007297

Discrimination of patients with type 2 myocardial infarction

Franz‐Josef Neumann, Nils A. Sörensen, Nicole Rübsamen, Francisco Ojeda, Thomas Renné et al. (13 authors)

European Heart Journal2017-07-20122 citations

10.1093/eurheartj/ehx457

Early diagnosis of acute myocardial infarction using high-sensitivity troponin I

Franz‐Josef Neumann, Nils A. Sörensen, Francisco Ojeda, Thomas Renné, Renate B. Schnabel et al. (9 authors)

PLoS ONE2017-03-2334 citations

10.1371/journal.pone.0174288

Challenging the 99th percentile: A lower troponin cutoff leads to low mortality of chest pain patients.

Sörensen NA, Neumann JT, Ojeda F, Schwemer T, Renné T, Schnabel RB, Zeller T, Karakas M, Blankenberg S, Westermann D.

2016-12-2720 citations

10.1016/j.ijcard.2016.12.167

Immediate Rule-Out of Acute Myocardial Infarction Using Electrocardiogram and Baseline High-Sensitivity Troponin I

Franz‐Josef Neumann, Nils A. Sörensen, Francisco Ojeda, Tjark Schwemer, Jonas Lehmacher et al. (23 authors)

Clinical Chemistry2016-11-3063 citations

10.1373/clinchem.2016.262659

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

No

Inclusion criteria

* Symptoms suggestive of acute myocardial infarction * Ability to provide written informed consent in accordance with Good epidemiological Practice and local legislation * Individuals at least 18 years old

Exclusion criteria

\- Insufficient knowledge of the German language (able to understand and write the German language)

Design outcomes

Primary

Measure	Time frame	Description
Acute myocardial infarction as index event	Months	The primary endpoint of the study is acute myocardial infarction

Secondary

Measure	Time frame	Description
AMI, Mortality, heart failure and quality of life	Years	The secondary endpoint of the study is mortality, heart failure, quality of life.

Countries

Germany

Contacts

Primary ContactJohannes T Neumann, MD

j.neumann@uke.de0049407410

Backup ContactNils Sörensen, MD

n.soerensen@uke.de0049407410

Outcome results