Doppler-based Renal Resistive Index in Assessing Renal Dysfunction Reversibility in ICU Patients

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02355314

Acronym

R2D2

Enrollment

367

Registered

2015-02-04

Start date

2013-12-31

Completion date

2016-05-31

Last updated

2016-09-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Kidney Injury

Keywords

ICU patients, Doppler-based renal

Brief summary

Acute kidney injury (AKI) is common in intensive care unit (ICU) patients and remains associated with a dismal prognosis. The diagnosis of AKI relies on functional criteria (oliguria and serum creatinine elevation), which carry several important limitations. Additionally, the investigators lack biomarker that may predict short term renal prognosis. Doppler-based renal resistive index (RI) measurement is a rapid and noninvasive investigative tool that may hold promise for early AKI detection in ICU patients or in differentiating transient from persistent AKI in selected critically ill patients. Although several studies have suggested adequate performance in predicting short-term reversibility of AKI, most of these studies were performed in limited patient samples. Additionally, a recent study has identified discrepant results regarding its diagnostic performance. The main objective of this large prospective multicentre study is to assess diagnostic performance of Doppler-based renal resistive index in diagnosing persistent AKI in critically ill patients requiring mechanical ventilation.

Interventions

OTHERDoppler-based renal

Doppler-based renal : day 0 and day 3

BIOLOGICALblood sample and urine sample

blood sample and urine sample : day 0 and day 3

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

DIAGNOSTIC

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Sinus rhythm * Use of conventional mechanical ventilation

Exclusion criteria

* Refusal: patient, family or trusted person to participate in the study * Renal artery stenosis known * Pregnant * Severe Chronic Renal Failure (clearance \< 30 ml.min-1)

Design outcomes

Primary

Measure	Time frame	Description
Doppler-based renal resistive index	Day 0	Doppler-based renal resistive index in diagnosing persistent AKI in critically ill patients requiring mechanical ventilation

Secondary

Measure	Time frame
Doppler-based renal resistive index	Day 3
Dosages NGAL plasmatique, NGAL urinaire, IGFBP-7, TIMP-2	Day 0
usual urinary indices (Fractional excretion of urea, fractional excretion of sodium, ratio U / P urea ratio U / P creatinine)	Day 0

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 5, 2026