Gestational Diabetes Mellitus
Conditions
Keywords
antioxidants, Gestational diabetes mellitus, oxidative stress
Brief summary
Fasting and two hours postprandial blood sugar were done to all cases between 28 and 32 weeks and high blood sugar levels were found so Cases were controlled by both diet and insulin. The 200 pregnant women with Gestational diabetes mellitus were randomized using automated web based randomization system into 2 groups, Group1 received 1 gram L-ascorbic acid (vitamin C )per day from the time of diagnosis until the time of delivery in addition to routine treatment of diabetes (diet & insulin). Group2 received only the treatment of diabetes
Detailed description
The 200 pregnant women with Gestational diabetes mellitus were randomized using automated web based randomization system into 2 groups, Group1 received 1 gram L-ascorbic acid oral once daily (vitamin C )per day from the time of diagnosis until the time of delivery in addition to routine treatment of diabetes (diet & insulin). Group2 received only the treatment of diabetes (diet and insulin
Interventions
DRUGL-ascorbic acid
1 gram L-ascorbic acid (vitamin C …..) per day from the time of diagnosis until the time of delivery
Sponsors
Cairo University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 40 Years
Healthy volunteers
No
Inclusion criteria
* Women with the diagnosis of GDM
Exclusion criteria
* Women with multiple pregnancies * Chronic medical disorders e.g. anemia * Hypertension * Liver disease or renal disease * Those with obstetric problems other than GDM (e.g. pre-eclampsia & antepartum hemorrhage) or smokers and women with preexisting type I or II diabetes mellitus were excluded from our study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| neonatal outcome assessed by neonatal ICU admission | 1 week after delivery |
Secondary
| Measure | Time frame |
|---|---|
| oxidative stress parameters: non enzymatic and enzymatic oxidative stress parameters in placental tissue homogenates in women with GDM named glutathione ,malondialdahyde,superoxide dismutase ,catalase and glutathione peroxidase | 9 months of pregnancy |
| oxidative stress parameters: non enzymatic and enzymatic oxidative stress parameters in maternal blood plasma/lysate in women with GDM named glutathione,superoxide dismutase ,catalase and glutathione peroxidase | 9 months of pregnancy |
| oxidative stress parameters: non enzymatic and enzymatic oxidative stress parameters in neonatal blood in women with GDM named malondialdahyde and superoxide dismutase | 9 months of pregnancy |
Countries
Egypt
Outcome results
None listed