Repair, Remodeling and Regeneration of the Bronchial Epithelium of COPD Patients

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02354677

Acronym

RRR

Enrollment

Registered

2015-02-03

Start date

2014-10-17

Completion date

2018-04-17

Last updated

2019-09-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

COPD, Heathy Volunteers, Smokers

Keywords

Bronchial epithelium, COPD, Repair, Remodelling, Club Cells

Brief summary

COPD is characterized by exagerated decline FEV1 related to obstructive non reversible airflow. This could be the consequence of structural changes and inflammatory pattern of the bronchial wall. Lesions could lead to normal but also abnormal remodeling specially in COPD including a decrease in Club cells number and function.There is no treatment actually available targeted to a normal repair of the epithelium. The objective of this work is to identify potential targets for reprograming bronchial epithelial cells I order to achieve a good repair.

Interventions

OTHERIn vitro experiments on bronchial epithelial cells

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

BASIC_SCIENCE

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

COPD - Smokers or ex smokers \> 30p/yr * FEV1/FVC \< 0.7 * With a fibroscopy prescription Smokers - Smokers or ex smokers \> 30p/yr * FEV1/FVC \> 0.7 * With a fibroscopy prescription Controls - age superior or equal to 18 * no smoker (for 5 years) * with a fibroscopy prescription

Exclusion criteria

* Xylocaine hypersensibility * Porphyria * severe hepatic failure * Epilepsy * Severe cardiac failure

Design outcomes

Primary

Measure	Time frame	Description
Full recovery one day after injury (yes / no) proportion of cells showing the repair, remodeling or regeneration of the epithelium (ciliated cells, mucus cells, Clara cells) in culture in air-liquid interface in the three groups	1 day	The study will be judged on the proportion of cells showing the repair, remodeling or regeneration of the epithelium (ciliated cells, mucus cells, Clara cells) in culture in air-liquid interface in the three groups.

Secondary

Measure	Time frame	Description
Measurement of apoptosis and inflammation (IL8)	24 months	Determine the molecular mechanisms and deleterious cell leading to poor repair of the epithelium in patients with COPD
Measure the effect of the CC10 protein secreted by Clara cells on the repair of the bronchial epithelium.	24 months	Measuring the reprogramming of the epithelium of COPD patients to a control-type epithelium

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026