Glycaemia
Conditions
Keywords
Fructo-oligosaccharides, Sugar-reduced foods, Postprandial glucose response
Brief summary
The study aims to evaluate the glycaemic and insulinaemic response of short-chain fructo-oligosaccharides (scFOS) used to replace sugars (e.g. dextrose) in foods.
Interventions
Sponsors
Syral
Institut Pasteur de Lille
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
* Body mass index (BMI) between 18.0 and 25.0 kg/m² (included) * Ready to keep the same volume of physical activity and the same dietary habits during the study and particularly 24 hours before each visit * Be used to have breakfast * Non-smoker for at least 3 months * For the female participant: not being pregnant or breastfeeding and using efficient birth control * Signed the consent form * Able to follow the instructions of the study * Health insured * Accepted to be included in the National Registry for biomedical research Volunteers (Fichier VRB, Volontaires Recherches Biomédicales).
Exclusion criteria
* Fasting blood glucose over 6.1 mmol/L (1.10 g/L) (or diabetes treated or not) * Fasting blood cholesterol over 6.35 mmol/L * Fasting blood triglycerides over 1.70 mmol/L (or history of insulinoma) * Fasting blood insulin under 20 mU/L * Fasting HbA1c under 7% * History of hypercholesterolemia, hypertension, diabetes or glucose intolerance treated or not * History of dietary allergies or coeliac disease * History of digestive system disease susceptible to modify digestion or absorption like Crohn's disease * Somatic or psychiatric disorders * Renal insufficiency (kidney failure) * SGOT or ALAT over 52.5 U/L * Smoker * Consuming more than 3 alcoholic beverage a day * Weight varied 3 kg the last 3 months
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Glycaemic response | 2 hours and 5 minutes | Blood glucose kinetics with 7 points. Analysis of the Area under the curve of glucose. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Insulinaemic response | 2 hours and 5 minutes | Blood insulin kinetics with 7 points. Analysis of the Area under the curve of insulin. |
| Blood glucose peak (Cmax) | One-time data (the highest one) within the 2hrs 5mins kinetics. | Peak of blood glucose during kinetics. |
| Blood insulin peak (Cmax) | One-time data (the highest one) within the 2hrs 5mins kinetics. | Peak of blood insulin during kinetics. |
| Glucose Tmax : time to reach the peak of blood glucose | One time within the 2hrs 5mins kinetics. | — |
| Insulin Tmax : time to reach the peak of blood insulin | One time within the 2hrs 5mins kinetics. | — |
Countries
France
Outcome results
None listed