Congenital Heart Disease
Conditions
Keywords
Congenital Heart Disease, Point-of-care coagulation monitoring, Rotaional Thromboelastometry
Brief summary
This prospective study will aim to globally assess the coagulopathy induced during cardiac surgery with cardiopulmonary bypass (CPB) in a large pediatric population. The investigators primary objective will be the understanding of CPB-induced coagulopathy based on demographic and surgical characteristics, and coagulation assays. Secondary objective will aim at determining the relationship between coagulation assays, postoperative blood loss, and transfusion requirements. The ultimate goal will be to design an algorithm using point-of-care monitoring that could be used to guide hemostatic therapies in neonates and children undergoing cardiac surgery.To do this, investigators will examine the coagulation in the laboratory based setting.
Interventions
OTHERPerioperative blood samples collection
Collect blood samples at 3 different points intra-operatively. Each blood sample will be run using rotational thromboelastometry to assess intraoperative coagulation
Sponsors
Boston Children's Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
No minimum to 12 Months
Healthy volunteers
No
Inclusion criteria
* Neonates weighing greater than 2.5 kg * Patients equal to or less than 12 months of age * Undergoing elective cardiac surgery with cardiopulmonary bypass
Exclusion criteria
* Emergent procedure * The patient is deemed to be in a moribund condition (American Society of Anesthesiology (ASA 5))
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Evidence of CPB-induced coagulopathy confirmed by coagulation assays | Over 6 months |
Countries
United States
Outcome results
None listed