Impact on Ovarian Reserve of Diode Laser vs Bipolar Coagulation of Endometriomas

The Impact on Ovarian Reserve of Diode Laser vs Bipolar Coagulation of Inner Lining of Ovarian Endometriomas After Laparoscopic Cystectomy: a Randomized Clinical Trial.

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02350452

Enrollment

Registered

2015-01-29

Start date

2015-01-31

Completion date

2016-02-29

Last updated

2016-04-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ovarian Endometrioma

Keywords

laparoscopic surgery, diode laser, AMH, AFC

Brief summary

Endometriosis is a benign chronic gynaecological disease that affects 10% of women of reproductive age and takes 40% of them to assisted reproduction techniques. The purpose of the study is to compare the antimüllerian marker (AMH) and antral follicular count (AFC) , with the most common serological markers of ovarian reserve. The investigators intend to confirm their clinical utility in the assessment of ovarian function, and to promote their use in predicting decreased ovarian reserve. The work therefore moreover arises the objective to validate the bibliographic data about using the laser for haemostasis after stripping endometriomas, to amplify knowledge available in the literature on the surgical treatment of ovarian endometriomas and on the diode laser application in minimally invasive surgery, appraising the trend of AFC and AMH levels and the possible surgical implications on fertility .

Interventions

PROCEDUREDiode laser coagulation

Diode laser coagulation of inner lining of ovarian endometrioma after laparoscopic cystectomy

PROCEDUREBipolar coagulation

Bipolar coagulation of inner lining of ovarian endometrioma after laparoscopic cystectomy

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 40 Years

Healthy volunteers

Yes

Inclusion criteria

* regular menstrual cycles * unilateral endometrioma greater than 35 mm * no gynecological surgery 3-6 months before surgery * no hormonal therapy 1 month before surgery

Exclusion criteria

* previous surgery for endometriosis * hormone therapy in the month before the current surgery * coagulation disorders * ongoing pregnancy * pelvic inflammatory disease * malignant disorders * cysts otherwise * Gonadotropin-releasing hormone analogues or contraceptive therapy during the follow-up * BMI≥ 30 kg/m2 * endocrinological disorders * unable or unwilling to give written consent

Design outcomes

Primary

Measure	Time frame
Anti-Müllerian hormone (AMH) serum levels	Change from AMH serum levels at 3 months after surgery

Secondary

Measure	Time frame
Antral follicular count (AFC)	Change from AFC at 3 months after surgery, during early follicular phase

Countries

Italy

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026