Cushing Disease
Conditions
Keywords
Mortality, Morbidity, Incidence, Prevalence
Brief summary
The purpose of this study is to study since 1987 all patients diagnosed with CD in Sweden and determine their outcomes including mortality. A secondary objective is to focus on patients in remission and identify determinants of their different outcomes.
Detailed description
This study is a retrospective nationwide study of all patients in Sweden with diagnosis CD between 1987 and 2013 were baseline data at diagnosis, information about the different treatments and follow-up data is going to be obtained by reviewing patients' medical journals. This information as well as the exact diagnose criteria for each patient are going to be extracted by Endocrinologists in all University Hospitals in Sweden. An expert group at the Sahlgrenska University Hospital in Gothenburg will put together the data.By the use of the Swedish Personal Number, the investigators are going to obtain information about both patients' and background population co-morbidities which have been collected in the different Swedish Registers. Primary aim: To study mortality of CD in Sweden. Secondary aims: 1. To study the influence of CD on myocardial infarction 2. To study the influence of CD on stroke 3. To study the influence of CD on cancer 4. To study the influence of CD on hip fracture risk 5. To study incidence and prevalence of CD in Sweden.
Interventions
None listed
Sponsors
Vastra Gotaland Region
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* All patients registered with Cushing's Disease in Sweden since 1987 in the statistical database for in- and out-patients, at the Swedish National Board of Health and Welfare will be included in the study.
Exclusion criteria
* No
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Mortality | From date of diagnosis until the last day of December 2014 or date of death from any cause, whichever came first, assessed up to 20 years. | If event (death) has been occured during the observation period. Data obtained by the Swedish Cause Of Death Register (Swedish Board of Health and Welfare) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| influence of Cushing's Disease on stroke | From date of diagnosis until the last day of December 2014 or date of death from any cause, whichever came first, assessed up to 20 years | If event (stroke) has been occured during the observation period.Data obtained by the Swedish Register of In- and Out-patient Diagnoses (Swedish Board of Health and Welfare) |
| influence of Cushing's Disease on cancer | From date of diagnosis until the last day of December 2014 or date of death from any cause, whichever came first, assessed up to 20 years | If event (cancer) has been occured during the observation period.Data obtained by the Swedish Register of Cancer Diagnoses (Swedish Board of Health and Welfare) |
| influence of Cushing's Disease on myocardial infarction | From date of diagnosis until the last day of December 2014 or date of death from any cause, whichever came first, assessed up to 20 years | If event (myocardial infarction) has been occured during the observation period.Data obtained by the Swedish Register of In- and Out-patient Diagnoses (Swedish Board of Health and Welfare) |
| incidence of Cushing's Disease in Sweden | Assessed up to 20 years. | Validation of Data obtained by The Swedish Board of Health and Welfare by reviewing all patients' journals |
| prevalence of Cushing's Disease in Sweden | Assessed up to 20 years. | Validation of Data obtained by The Swedish Board of Health and Welfare by reviewing all patients' journals |
| influence of Cushing's Disease on hip fracture risk | From date of diagnosis until the last day of December 2014 or date of death from any cause, whichever came first, assessed up to 20 years | If event (hip fracture) has been occured during the observation period.Data obtained by the Swedish Register of Hip Fractures (Swedish Board of Health and Welfare) |
Countries
Sweden
Outcome results
None listed