Endometrial Scratch Injury in Women With Unexplained Infertility Undergoing IUI

Endometrial Scratch Injury Induced Higher Pregnancy Rate for Women With Unexplained Infertility Undergoing IUI With Ovarian Stimulation

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02349750

Enrollment

154

Registered

2015-01-29

Start date

2010-01-31

Completion date

2013-01-31

Last updated

2015-01-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Unexplained Infertility

Keywords

Endometrial Scratch Injury, Unexplained infertility, intrauterine insemenation, ovulation induction

Brief summary

The study included 154 infertile women Patients received 100 mg of oral clomiphene citrate for five days starting on day 3 of the menstrual cycle, followed by daily injection of 150 IU of hMG and when more than two dominant follicles reached a diameter of 17 mm 5,000 IU of hCG was injected intramuscularly. Patients were randomly allocated into two equal groups: Group C received IUI without ESI and Group S had ESI using No.8 neonatal feeding tube and after 24 to 36 hours, IUI was performed. Successful pregnancy was con-firmed by ultrasound and patients had failed trial underwent another trial of IUI for a maximum of three trials.

Detailed description

The study included 154 infertile women with mean duration of infertility of 3.9±0.4 years. Patients received 100 mg of oral clomiphene citrate for five days starting on day 3 of the menstrual cycle, followed by daily injection of 150 IU of hMG and when more than two dominant follicles reached a diameter of 17 mm 5,000 IU of hCG was injected intramuscularly. Patients were randomly allocated into two equal groups: Group C received IUI without ESI and Group S had ESI using No.8 neonatal feeding tube and after 24 to 36 hours, IUI was performed. Successful pregnancy was con-firmed by ultrasound and patients had failed trial underwent another trial of IUI for a maximum of three trials.

Interventions

PROCEDUREendometrial scratch injury

ESI using No.8 neonatal feeding tube

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

FEMALE

Age

20 Years to 40 Years

Healthy volunteers

Inclusion criteria

1\. Couple with unexplained infertility and assigned for IUI

Exclusion criteria

1. Woman's age of more than 40 years 2. Ovarian cyst detected in the ultrasound examination 3. Uterine lesions such as submucosal leiomyoma 4. A previous diagnosis of moderate to severe pelvic endometriosis 5. Women with body mass index ≥35 kg/m2 o 6. Women with signs of hyperandrogenemia dy

Design outcomes

Primary

Measure	Time frame
clinical pregnancy	14 days after IUI

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026