Effects of; Serum, Urine Marking
Conditions
Keywords
Biological markers, Cartilage
Brief summary
The purposes of the study are to assess intra individual biological variability of serum and urinary cartilage specific biomarkers and define the best standardized conditions for blood and urine sampling in the frame of biomarkers dosage.
Detailed description
To assess intra individual biological variability of serum and urinary cartilage specific biomarkers and define the best standardized conditions for blood and urine sampling in the frame of biomarkers dosage. Variation factors assessed are: * Fasting condition * Sampling time * Sampling season * Physical activity * Duration and temperature of total blood treatment * Type of blood collection tube.
Interventions
OTHERserum and urine sample
Serum and urine samples will be collected at baseline, weeks2, 16, 52 and 68 to assess intra-individual biological variability of cartilage-specific biomarkers Coll2-1/Coll2-1NO2 / FIB3-1 and FIB3-2.
Sponsors
Artialis
Study design
Observational model
COHORT
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Male or female, aged above 18 years. * Sign an informed consent after being informed * Able to follow the instructions of the study
Exclusion criteria
* Serious associated diseases: * Severe liver disease * Renal failure * HIV * hepatitis B or C * Patient who are the subject of a judicial protection measure or under guardianship
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Variation of serum and urine sample between baseline, weeks 2, 16, 52 and 68 to assess intra-individual biological variability of cartilage-specific biomarkers Coll2-1/Coll2-1NO2 / FIB3-1 and FIB3-2. | Baseline and weeks 2, 16, 52 and 68 | Change from baseline will be assess by biomarkers dosage using ELISA (Enzyme Linked ImmunoAssay) |
Countries
Belgium
Outcome results
None listed