Leukemia, Lymphoma
Conditions
Keywords
leukemia, lymphoma, lumbar puncture, intrathecal treatment, post-lumbar puncture headache
Brief summary
Headache following a lumbar puncture （post-lumbar-puncture headache,PLPH）is a common and often debilitating syndrome, which was reported to occur in about 40% patients who received lumbar puncture. Now there lacks of effective approaches in the prophylaxis of PLPH, although some physicians consider bed rest for at least 6 hours to be a useful methods (Some recent meta-analysis found no benefit of bed rest for any hours in the prevention of PLPH). Studies have found that P substances and its receptor (Neurokinin-1 receptor, NK-1R)have played an important role in the pathogenesis of PLPH. Thus, we hypothesize that use of NK-1R inhibitor (aprepitant) 1 hour before lumbar puncture may decrease the incidence of PLPH and lower the severity of PLPH.
Detailed description
Headache following a lumbar puncture （post-lumbar-puncture headache,PLPH）is a common and often debilitating syndrome, which was reported to occur in about 40% patients who received lumbar puncture. Now there lacks of effective approaches in the prophylaxis of PLPH, although some physicians consider bed rest for at least 6 hours to be a useful methods (Some recent meta-analysis found no benefit of bed rest for any hours in the prevention of PLPH). Studies have found that P substances and its receptor (Neurokinin-1 receptor, NK-1R)have played an important role in the pathogenesis of PLPH. Thus, we hypothesize that use of NK-1R inhibitor (aprepitant) 1 hour before lumbar puncture may decrease the incidence of PLPH and lower the severity of PLPH.
Interventions
DRUGAprepitant
use aprepitant 1 hour before lumbar puncture and intrathecal treatment
Sponsors
Sun Yat-sen University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
16 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Patients diagnosed as acute leukemia, or lymphoma * Patients will received repeated lumbar puncture (at least 2 times, and at least 2 weeks apart) and intrathecal treatment * Without CNS involvement * Without headache for at least 1 week before the day of lumbar puncture * The platelet count was at least 30×10e9/L
Exclusion criteria
* With CNS involvement of disease * With headache before lumbar puncture * Needs lumbar puncture more than once a week
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| incidence of any grade post-lumbar-puncture headache | date from the day of lumbar puncture to 2 weeks after lumbar puncture |
Secondary
| Measure | Time frame |
|---|---|
| incidence of grade 3/4 post-lumbar-puncture headache | date from the day of lumbar puncture to 2 weeks after lumbar puncture |
Countries
China
Contacts
Primary ContactLiang Wang, doctor
Outcome results
None listed