Metabolic Syndrome, Obesity
Conditions
Brief summary
The experimental model is a semi-acute, over-night, study where the purpose is to evaluate food factors related to colonially derived regulation and satiety in healthy subjects.
Interventions
OTHERHigh levels of indigestible carbohydrates
OTHERLow levels of indigestible carbohydrates
Sponsors
Lund University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
PREVENTION
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
20 Years to 35 Years
Healthy volunteers
Yes
Inclusion criteria
* Normal fasting blood glucose * BMI 19-25 kg/m2
Exclusion criteria
* Gastrointestinal diseases * Food allergies e.g. lactose-, gluten intolerance * Metabolic disorder e.g. diabetes * Tobacco/snuff users * No antibiotic or probiotic intake 2 weeks prior and during study. * Vegetarians
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood Glucose, levels of glucose in blood | Postprandial 0-180 min after breakfast |
| Insulin, levels of insulin in blood | Postprandial 0-180 min after breakfast |
| Appetite hormones, levels of Peptide YY (PYY) in blood | Postprandial 0-180 min after breakfast |
| Markers of colonic fermentation, levels of hydrogen in breath | Postprandial 0-180 min after breakfast |
| Inflammation markers, levels of Interleukin-6 (IL-6) in blood | Postprandial 0-180 min after breakfast |
Secondary
| Measure | Time frame |
|---|---|
| Subjective satiety, as measured by VAS | Postprandial 0-180 min after breakfast |
Countries
Sweden
Outcome results
None listed