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The Impact of Sucrose Ingestion Post-Exercise on Liver and Muscle Glycogen Repletion.

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT02344381
Enrollment
15
Registered
2015-01-26
Start date
2015-01-31
Completion date
2015-05-31
Last updated
2015-10-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Liver and Muscle Glycogen Replenishment Post-exercise

Brief summary

Carbohydrate is stored in the body as glycogen, which is mainly found in the liver and muscle. During endurance exercise, muscle glycogen is used as fuel for the working muscles and liver glycogen is broken down to provide glucose to maintain blood glucose (sugar) levels. Both liver and muscle glycogen are important for our ability to perform intense/prolonged endurance exercise. Therefore, it is important to replete these stores after an intense/prolonged endurance exercise session in order to recover and perform optimally during a subsequent exercise bout, especially if the next exercise session is within 24h (e.g. stage races such as the Tour de France, tournament-style competitions such as the Olympic games and ultra-endurance events). Carbohydrate intake has been shown to increase the availability of glycogen in the muscle and liver after exercise. The carbohydrates typically found in sports drinks are glucose and sometimes fructose. It has been observed that the ingestion of glucose will lead to a maximum rate of absorption of approximately \ 1 g/min. However, if we also provide a different source of carbohydrate (fructose) then this is absorbed through a different pathway and therefore we can absorb up to \ 1.75 g/min of carbohydrate. In addition, both carbohydrate sources are metabolised differently in the human body. By supplementing both glucose and fructose, we can potentially replenish the liver and muscle glycogen stores at a faster rate than ingestion of glucose only. Sucrose is a naturally occurring sugar that is made up of a single glucose and single fructose molecule. Therefore, theoretically, this can use the two different pathways of absorption and also maximise carbohydrate delivery. It is not yet known however, what impact this has on our liver and muscle glycogen stores post-exercise when supplemented in relatively high amounts. Therefore the aim of this study is to assess whether relative high amounts of sucrose ingestion will improve liver and muscle glycogen repletion after endurance exercise.

Interventions

DIETARY_SUPPLEMENTSucrose
DIETARY_SUPPLEMENTGlucose

Sponsors

Maastricht University
CollaboratorOTHER
Newcastle University
CollaboratorOTHER
Sugar Nutrition
CollaboratorUNKNOWN
Northumbria University
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender
MALE
Age
18 Years to 35 Years
Healthy volunteers
Yes

Inclusion criteria

* Healthy * Endurance trained cyclists/triathletes * VO2 max ≥ 50 ml/kg/min

Exclusion criteria

* Use of medication * Smoking * Metabolic disorders

Design outcomes

Primary

MeasureTime frameDescription
change in liver glycogen concentration5 hThe change in liver glycogen content will be determined post-exercise using 13C magnetic resonance spectroscopy

Secondary

MeasureTime frameDescription
Change in muscle glycogen concentration5 hThe change in muscle glycogen content will be determined post-exercise using 13C magnetic resonance spectroscopy
Plasma glucose concentration5 h
Plasma insulin concentration5 h
Plasma lactate concentration5 h

Countries

United Kingdom

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026