Pain
Conditions
Keywords
Sucrose, Anesthesia, Blood specimen collection, Injections, Intravenous
Brief summary
Despite the fact that oral sucrose is the most frequently studied non-pharmacological intervention for procedural pain relief in infants, there is a paucity of data on the minimal effective dose. The aim of this study is to find the minimal effective dose of sucrose to reduce pain during a single venous blood sampling procedure.
Interventions
OTHER0.2 ml sucrose 25%
Administered on the tongue by a syringe, a half dose two minutes before blood sampling and the other half dose immediately before sampling
OTHER0.5 ml sucrose 25%
Administered on the tongue by a syringe, a half dose two minutes before blood sampling and the other half dose immediately before sampling
Sponsors
St. Olavs Hospital
Lower Umfolozi Regional War Memorial Hospital
Norwegian University of Science and Technology
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
No minimum to 8 Weeks
Healthy volunteers
No
Inclusion criteria
* born preterm * more than 1000 gram
Exclusion criteria
* severe intraventricular hemorrhage * cerebral malformations * other malformations requiring surgery * medication that may impair pain expression (opioids, paracetamol, sedatives)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| pain | 1 week | assessed by Premature Infant Pain Profile-Revised (PIPP-R). Pain score related to the blood sampling will be performed two times: at skin puncture and immediately after the needle has been removed |
Countries
Norway, South Africa
Outcome results
None listed