Liver Cirrhosis
Conditions
Keywords
Malnutrition, Muscle mass, Nutrition
Brief summary
The purpose is to investigate the effect of strength training on muscle strength, muscle mass and nutritional status in patients with liver cirrhosis to clarify possible metabolic and inflammatory changes during this intervention. In addition the investigator examine if the intervention is associated with fewer hospital readmission and an improved quality of life.
Interventions
BEHAVIORALNutrition and strength training
All participants will receive professional dietary guidance and a protein supplement. At the beginning and end of the intervention every participant will be part of a program consisting of: Test of muscle strength, blood samples, assessment of nutritional status, MRi scan, test of Quality of life by questionnaire and test of the ammonium metabolism. After one year readmissions will by registered. The intervention group will receive supervised training.
BEHAVIORALNutrition
All participants will receive professional dietary guidance and a protein supplement. At the beginning and end of the intervention every participant will be part of a program consisting of: Test of muscle strength, blood samples, assessment of nutritional status, MRi scan, test of Quality of life by questionnaire and test of the ammonium metabolism. After one year readmissions will by registered.
Sponsors
Aarhus University Hospital
University of Aarhus
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Cirrhosis, Child Pugh score A and B
Exclusion criteria
* Cirrhosis, Child-Pugh score C at inclusion * Neurological and/or psychiatric disorder * Pregnancy, breastfeeding * Patients with malignancy * Patients with hepatic encephalopathy at inclusion * Patients with atypical diets, such as vegans
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Maximal voluntary muscle strength in knee extensor will be measured by an isokinetic dynamometer and hand strength by hand dynamometer. | 12-14 weeks |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Readmissions as measured by a follow-up one year after the intervention. | 1-1,5 year | — |
| Quality of Life as measured by a standardized questionnaire (SF-36) | 12-14 weeks | — |
| Nutritional status as measured by Triceps skinfold thickness (TSF), mid-upper-arm circumference (MUAC), mid-arm muscle area (MAMA) and hand dynamometer | 12-14 weeks | — |
| Ammonia metabolism as measured by Oral Glutamine Challenge Test | 12-14 weeks | Minimal risk in the taking of blood samples. The participant can experience nausea and dizziness but will not be left unsupervised during the test. |
| Muscle mass as measured by MRi scan and bioimpedance scan. | 12-14weeks | — |
| Insulin sensitivity as measured by HOMA-IR | 12-14 weeks | — |
Countries
Denmark
Outcome results
None listed