Lymphoma, Follicular, Lymphoma, Large B-Cell, Diffuse
Conditions
Keywords
Phase 1, Oral Azacitidine (CC-486), R-CHOP, Diffuse Large B-cell Lymphoma, Grade 3B Follicular Lymphoma, Follicular Lymphoma, Transformed Lymphoma
Brief summary
The goal of the study is to identify a dose and schedule of CC-486 that can be safely administered with R-CHOP. To evaluate the safety and maximum tolerated dose (MTD) or the maximal administered dose (MAD) of CC-486 in combination with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) in subjects with high risk (IPI 2 or more) previously untreated DLBCL or Grade 3B FL. Also, to determine pharmacokinetics (PK) of CC-486 when administered alone and in combination with R-CHOP and to explore preliminary efficacy of CC-486 plus R-CHOP by 2007 International Working Group (IWG) criteria.
Detailed description
The purpose of this study is to evaluate the safety of oral azacitidine (CC-486) when combined with R-CHOP (the treatment regimen normally used in treating Diffuse large B-cell lymphoma or Grade 3B follicular lymphoma). This study also proposes to explore the pharmacokinetics of oral azacitidine when administered in combination with R-CHOP and to assess the effects the drug can have on the human body, as well as the ability of CC 486 in combination with R CHOP to further effect the response of tumors associated with Diffuse large B-cell lymphoma or Grade 3B follicular lymphoma, . Oral azacitidine in combination with R-CHOP has not been approved for the treatment of Diffuse large B-cell lymphoma or Grade 3B follicular lymphoma and its use in this study is investigational. Various dose levels of this investigation treatment will be administered to subject enrolled into the study. This study is separated into three periods: Screening and Registration, Treatment and Follow-up periods. Before the patient can receive the study drug the doctor will perform tests to find out whether he/she can participate in the study. This is done during the Screening Period. If the patient and the treating physician determine that the patient is eligible to participate in the study, the patient will be registered in the study and assigned to receive one of the investigational dose levels of oral azacitidine. The Treatment period starts when the patient receives their first dose of the study drug. The maximum time the patient will receive study treatment is 5 months. The intent is for the patient to complete 6 cycles of treatment. Each cycle will be 21 days. The Follow-up period starts when the patient's treatment is completed or discontinued for any reason. The patient will have fewer exams, tests and visits once entering the follow-up period. These visits will be every 6 months for up to 2 years.
Interventions
DRUGOral Azacitidine
DRUGRituximab
DRUGcyclophosphamide
DRUGVincristine
DRUGPrednisone
Sponsors
Celgene
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Histologically confirmed previously untreated DLBCL or Grade 3B FL, \[double-positive for BCL2 and c-MYC\] or transformed lymphoma. Transformed lymphoma from FL or marginal zone lymphoma, but not chronic lymphocytic leukemia (CLL) \[Richter Transformation\] are allowed as long as no prior anti-lymphoma therapy of any kind has been administered. 1. A formalin fixed paraffin embedded lymph node or tumor biopsy specimen must be submitted during the Screening Period. The specimen must have been acquired by a surgical or core needle biopsy (≥ 2 cores at baseline); material from a fine needle aspiration is not acceptable. 2. Fresh core biopsy, frozen, must be performed before start of therapy and submitted for storage. This is optional only for the subjects who have a biopsy-accessible site and consent to the procedure. In case no prior fixed formalin paraffin embedded (FFPE) biopsy is available, this specimen can also be used for diagnostic confirmation. 3. No prior anti-lymphoma therapy. However, for subjects with bulky disease,systemic symptoms, compressive disease, or rapidly progressing adenopathies, pre-phase treatment with 1 mg/kg/day prednisone, or equivalent, for a maximum of 7 days is permitted prior to Cycle 1 Day -6 at the discretion of the Investigator. In exceptional cases, if clinically indicated, a higher dose of steroids and/or a slightly longer duration is allowed for the purpose of urgent symptom management, and the subjects is considered eligible. A washout period does not apply. However the fresh core biopsy mentioned above should be performed before starting prednisone. 2. International Prognostic Index score ≥ 2 or DLBCL with double-positive for BCL2 and c-MYC by IHC (immunohistochemistry) or FISH (fluorescent in situ hybridization) based on local pathology lab assessment. 3. Measurable disease on cross section imaging by CT (computed tomography) that is at least 1.5 cm in the longest diameter and measurable in two perpendicular dimensions as defined by IWG (International Working Group) response criteria for NHL (non-Hodgkin Lymphoma). 4. Ann Arbor stage II to IV. 5. Men and women 18 years of age to 80 years of age of any ethnic origin or race at the time of signing the ICD. 6. Understand and voluntarily sign an ICD (Informed Consent Document) prior to any study related assessments/procedures are conducted. 7. Able to adhere to the study visit schedule and other protocol requirements. 8. Performance status ≤ 2 on the Eastern Cooperative Oncology Group (ECOG) scale. 9. Negative serum pregnancy test within 72 hours before starting study treatment on Cycle 1 Day -6 for females of childbearing potential (FCBP). A female of child-bearing potential, defined as a sexually mature woman who: 1) has not undergone a hysterectomy (the surgical removal of the uterus) or bilateral oophorectomy (the surgical removal of both ovaries) or, 2) has not been naturally postmenopausal for at least 24 consecutive months (i.e., has had menses at any time during the preceding 24 consecutive months), may participate providing they agree to the following conditions: 1. Either commit to true abstinence\* from heterosexual contact (which must be reviewed on a monthly basis) or agree to the use of a physician-approved contraceptive method (oral, injectable, or implantable hormonal contraceptive; tubal ligation; intrauterine device; barrier contraceptive with spermicide; or vasectomized partner) without interruption, while on CC-486 (including dose interruptions); and for 3 months following the last dose of IP; and 2. Agree to have a medically supervised serum pregnancy test with sensitivity of at least 25 mIU/mL obtained at Screening. A serum pregnancy test is to be performed within 72 hours prior to Day 1 of starting study therapy on Cycle 1 Day -6, and within 72 hours prior to Day 1 of every subsequent cycle, and at the Treatment Discontinuation Visit. The subject may not receive IP until the Investigator has verified that the result of the pregnancy test is negative. 10. Male subjects with a female partner of childbearing potential must either commit to true abstinence\* or agree to the use of a physician-approved contraceptive method throughout the course of the study and avoid fathering a child during the course of the study and for 3 months following the last dose of the IP (Investigational Product).
Exclusion criteria
1. Any significant medical condition, laboratory abnormality, or psychiatric illness that would prevent the subject from participating in the study. 2. Any condition including the presence of laboratory abnormalities, which places the subject at unacceptable risk if he/she were to participate in the study. 3. Any condition that confounds the ability to interpret data from the study. 4. Any condition causing an inability to swallow tablets. 5. History of inflammatory bowel disease (e.g., Crohnis disease, ulcerative colitis),celiac disease (i.e., sprue), prior gastrectomy or upper bowel removal, or any other gastrointestinal disorder or defect that would interfere with absorption, distribution, metabolism, or excretion of the IP and/or predispose the subject to an increased risk of gastrointestinal toxicity. 6. Hematologic and Non-hematologic
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Maximum Tolerated Dose (MTD) | 1 year | The dose level corresponding to the target Dose Limiting Toxicity (DLT) probability of 0.20. |
| Maximal Administered Dose (MAD) | 1 Year | The highest recorded dose administered to a subject if the MTD is not reached |
| Adverse Event (AE) | 2 Years | Number of participants with adverse events |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Pharmacokinetics - t1/2 | 2 Years | Terminal half-life |
| Pharmacokinetics CL/F | 2 Years | Apparent total body clearance |
| Pharmacokinetics - Vz/F | 2 Years | Apparent volume of distribution |
| Pharmacokinetics- Cmax | 2 Years | Maximum observed concentration in plasma |
| Complete response (CR) rate | 4 Years | Efficacy evaluation of CC-486 plus R-CHOP of the percentage of subjects achieving Complete Remission as assessed by 2007 International Working Group (IWG) criteria for non-Hodgkin lymphoma as evaluated by investigator review. |
| Progression free survival (PFS) | 4 Years | Efficacy evaluation of CC-486 plus R-CHOP. Progression-free survival is calculated as the time from C1D1 to the first documented progression or death due to any cause. Progression will be assessed by 2007 International Working Group (IWG) criteria for non-Hodgkin lymphoma as evaluated by investigator review. |
| Overall response rate (ORR) | 4 Years | Efficacy evaluation of CC-486 plus R-CHOP of the percentage of subjects achieving and clinical response (Complete or Partial Remission) as assessed by 2007 International Working Group (IWG) criteria for non-Hodgkin lymphoma as evaluated by investigator review. |
| Pharmacokinetics - AUC | 2 Years | Area under the concentration-time curve |
| Pharmacokinetics - Tmax | 2 Years | Time to maximum concentration |
Countries
United States
Outcome results
None listed