Is the Efficacy of Epidural Steroid Injections Related to the Different Volume Injections?

Is the Efficacy of Epidural Steroid Injections Related to the Different Volume Injections? :A Randomised, Clinical Trial

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02343432

Enrollment

Registered

2015-01-22

Start date

2008-03-31

Completion date

2008-09-30

Last updated

2015-01-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pain

Keywords

Anesthesia, Adverse Effect, Spinal, Epidural

Brief summary

This study was aimed to investigate the impact of using different epidural volumes. Patients with acute discogenic pain were included in the study.

Detailed description

Objectives: This study was aimed to investigate the impact of using different epidural volumes. Methods: Seventy five patients with acute discogenic pain were included in the study.The patients were randomly assigned to three groups. All patients received a single epidural dose of triamcinolone \[80 mg\] and 12.5 mg bupivacaine combination. The patients in Group 1, Group 2 and Group 3 received a volume of 10 mL, 15 mL, and 20 mL by epidural injections, respectively. The efficacy of treatment was assessed with VAS (visual analog scale) \[O= no pain, 10 = unbearable pain\], SLET(straight leg elevation test) \[0° = worst, 85° = best\], and Oswestry Disability Index; ODI \[0% to 20%:minimal disability , 80% to 100%:bed bound patients\] before and 2 weeks after the EPSI.

Interventions

DRUGTriamcinolone

Triamcinolone

DRUGEpidural Volume

Epidural Volume

DRUGBupivacaine

Bupivacaine

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

ALL

Age

25 Years to 60 Years

Healthy volunteers

Yes

Inclusion criteria

* acute discogenic pain with less than three months duration not responding to other modalities of conservative management \[NSAIDs, physiotherapy, bracing, etc.\], * radiological disc bulging accompanying unilateral root impingement symptoms, * an Oswestry daily activity score more than 20 percent, and * resistance to treatment.

Exclusion criteria

* Patients with bilateral root impingement symptoms, neurological deficits, and/or history of previous lumbar disc surgery, severe cardiac, pulmonary, gastrointestinal, renal diseases, glaucoma, urinary retention, and/or known allergy to the drugs used in the study were excluded from the study.

Design outcomes

Primary

Measure	Time frame
VAS (visual analog scale) [O= no pain, 10 = unbearable pain]	2 weeks
SLET(straight leg elevation test) [0° = worst, 85° = best]	2 weeks
Oswestry Disability Index; ODI [0% to 20%:minimal disability , 80% to 100%:bed bound patients]	2 weeks

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026