Kidney Failure, Liver Failure
Conditions
Brief summary
The aim of the investigators work is to describe the agreement between NIRS and ecodoppler, as monitoring systems of liver and kidney graft's perfusion in the immediate postoperative period in pediatric patients.
Detailed description
This is an observational descriptive pilot study to explore the Somanetics INVOS® system performance. In this study the investigators will recruit a convenient number of patients, 15 patients, that will be admitted to our ICU after liver/kidney transplantation, in a 6 month period. The Primary endpoint will be the correlation between hepatic/renal NIRS measurements and graft's artery resistance indices, as evaluated with ecodoppler. The Secondary endpoints will be: * The Correlation between NIRS measurements and biochemical indicators of graft function (NGAL for kidney transplantation and INR, SGOT/SGPT, bilirubin, lactate for liver transplantation) * The Correlation between NIRS measurements and SvO2 values
Interventions
NIRS is a non invasive monitoring system that enables assessment of tissue oxygenation through a quantitative estimation of haemoglobin oxygen-saturation within tissues.
Sponsors
Medtronic - MITG
Mariella Enoc
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
No minimum to 17 Years
Healthy volunteers
No
Inclusion criteria
* All pediatric patients admitted to our ICU for postoperative care after liver/kidney transplantation
Exclusion criteria
* Obesity (BMI \> 35) * Presence of a surgical plate over the graft * Impossibility of probe positioning, because of surgical wound, medication or drainage * Bilirubin level \> 30 mg/dL
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| hepatic/renal NIRS measurements and graft's artery resistance indices, as evaluated with ecodoppler | every hour from recovery time to 6 hours after extubation |
Secondary
| Measure | Time frame |
|---|---|
| hepatic/renal NIRS measurements and biochemical indicators of graft function: - NGAL for kidney transplantation - INR, SGOT/SGPT, bilirubin, lactate for liver transplantation | every hour until from recovery to 6 hours after extubation |
| hepatic/renal NIRS measurements and SvO2 values | every hour from recovery to 6 hours after extubation |
Countries
Italy
Outcome results
None listed