Increased Intestinal Permeability, Low-grade Inflammation
Conditions
Brief summary
The purpose of this study is to evaluate the ability of a blend of berries and probiotics in reducing low-grade inflammation and intestinal permeability in the elderly. The intervention period is one month. Blood and fecal samples will be collected for analysis at baseline and at the end of the intervention with the aim to analyse possible changes in different parameters at the two timepoints. The participants will also be asked to keep a study diary throughout the study period for the documentation of their intestinal health and as a means for checking compliance.
Interventions
DIETARY_SUPPLEMENTPlacebo
Powder
DIETARY_SUPPLEMENTActive, only probiotics
Powder
DIETARY_SUPPLEMENTActive, blend of berries and probiotics
Powder
Sponsors
Lund University
Probi AB
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Caregiver, Investigator)
Eligibility
Sex/Gender
ALL
Age
75 Years to 90 Years
Healthy volunteers
Yes
Inclusion criteria
* Age \>75 years * CRP 2-10 mg/L * Ability to fill in a study diary by him/herself
Exclusion criteria
* Intake of antibiotic treatment in the last 4 weeks before inclusion into the study. * Currently on corticosteroid treatment * Presence of chronic inflammatory disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Reduced intestinal permebility measured as decline in the levels of zonulin in blood samples | All blood markers analysed in the study will be measured at start, before the onset of intervention and 4 weeks later at the end of intervention. |
Countries
Sweden
Outcome results
None listed