Pterygium
Conditions
Keywords
pterygium, ranibizumab, anti-VEGF, recurrence, vascularity, size
Brief summary
The purpose of this study is to evaluate the pterygium vascularity and size before and after intralesional ranibizumab injection and to evaluate its recurrence rate following pterygium excision surgery.
Detailed description
The purpose of this study is to: 1. Compare the vascularity of primary pterygium before and 1 week after intralesional ranibizumab (0.3 mg/0.03 mL) injection. 2. Compare the size of primary pterygium before and 1 week after intralesional ranibizumab (0.3 mg/0.03 mL) injection. 3. Compare the recurrence rate at 1 year after pterygium excision surgery between the group with and without intralesional ranibizumab injection.
Interventions
DRUGranibizumab
Intralesional ranibizumab 0.3 mg/0.03mL injected 1 week before pterygium excision surgery.
Sponsors
Universiti Sains Malaysia
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* All patients with primary pterygium. * Grade T3 (fleshy) pterygium.
Exclusion criteria
* Patients with other ocular surface disorders. * Previous ocular surgery or trauma. * History of systemic thromboembolic event. * Pregnant women and lactating mother.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| pterygium recurrence | 1 year | pterygium recurrence is defined as true recurrence with a fibrovascular tissue invading the cornea (grade 4 lesion) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| pterygium vessel area | 1 week | Pterygium vesel area is defined as the as the ration of pixels occupied by the vessels within the pterygium area in percentage. |
| corneal pterygium area | 1 week | Corneal pterygium area is defined as the as the ration of pixels occupied by the pterygium within the cornea area in percentage. |
Outcome results
None listed