Disorder of Phosphate, Calcium and Vitamin D Metabolism, Female Infertility Due to Diminished Ovarian Reserve, Hormonal Requirement, Reproductive Disorder
Conditions
Keywords
Egg donation, vitaminD, ovarian reserve, ovarian stimulation
Brief summary
Objective: To investigate the correlation between total and bioavailable serum 25-OH vitamin D, ovarian reserve and ovarian response to controlled stimulation in egg donors.
Detailed description
Design: Retrospective study. Setting: University affiliated private IVF center. Intervention: Serum analysis of vitamin D, bioavailable vitamin D, antimullerian hormone (AMH), antral follicular count (AFC), reproductive outcome of oocytes recipients Main outcome measure: AMH, AFC, number of oocytes retrieved and number of mature oocytes, pregnancy and implantation rate of donated oocytes'recipients.
Interventions
OTHERvitamin D,AMH, AFC, reproductive outcome egg recipients
observational study of 269 donnors
Sponsors
IVI Madrid
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 34 Years
Healthy volunteers
No
Inclusion criteria
* Caucasian race, * between 18 and 34 years of age, * all donors had normal menstrual cycles of 26-34 days, * normal weight range (BMI 18- 25 Kg/m2), * normal uterus and ovaries on transvaginal ultrasound (no signs of polycystic ovarian syndrome), and * an antral follicle count (AFC) \>10, * normal karyotype
Exclusion criteria
* current or past exposure to radiation or hazardous chemical substances, * history of drug use, * family history of hereditary chromosomal diseases, * sexually transmitted diseases
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Numbers of oocytes retrieved | 2 months |
Secondary
| Measure | Time frame |
|---|---|
| implantation rate | 2 months |
| pregnancy rate | 2 months |
| AFC | 2 months |
| number of mature oocytes | 2 months |
| AMH | 2 months |
Outcome results
None listed