Diagnostic Accuracy of Nontuberculous Mycobacterial Lung Disease Based on Chest CT

Diagnostic Accuracy and Inter-rater Agreement of Chest Computed Tomography in the Diagnosis of Nontuberculous Mycobacterial Lung Disease

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02340897

Enrollment

132

Registered

2015-01-19

Start date

2014-12-31

Completion date

2015-03-31

Last updated

2016-04-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Mycobacterium Infections, Nontuberculous

Brief summary

The aim of this study was to elucidate the accuracy and inter-rater agreement of diagnosis of nontuberculous mycobacterial lung disease based on chest computed tomography findings.

Detailed description

To elucidate the accuracy and inter-rater agreement of diagnosis of nontuberculous mycobacterial lung disease based on chest CT, two pulmonologists and two chest radiologists were requested to interpret chest CT of patients nontuberculous mycobacterial lung disease satisfying diagnostic criteria of American Thoracic Society as well as British Thoracic Society, or pulmonary tuberculosis. Two pulmonologists and two chest radiologists \> 10 years of clinical experiences at a tertiary referral hospital participated as raters in this study. They were blinded to the any clinical information of the patients including the specific diagnosis, except age and sex. The interpretations of four raters were analyzed and compared.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

* Nontuberculous mycobacterial patients satisfying diagnostic criteria suggested by American Thoracic Society * Patients with bacteriologically confirmed pulmonary tuberculosis * Patients with bronchiectasis, confirmed by clinically as well as radiographically

Exclusion criteria

* None

Design outcomes

Primary

Measure	Time frame	Description
Sensitivity for the diagnosis of nontuberculous mycobacterial lung disease	baseline	Percentage of cases diagnosed as nontuberculous mycobacterial lung disease by four raters out of confirmed cases with nontuberculous mycobacterial lung disease

Secondary

Measure	Time frame	Description
Inter-rater correlation (kappa value) for the diagnosis of nontuberculous mycobacterial lung disease	baseline	Inter-rater correlation between four raters
Specificity for the diagnosis nontuberculous mycobacterial lung disease	baseline	Percentage of cases diagnosed as other than nontuberculous mycobacterial lung disease by four raters out of confirmed cases with other than nontuberculous mycobacterial lung disease

Outcome results