Basal Metabolic Rate, Cardiovascular Risk Factors
Conditions
Brief summary
Randomized trial of supplying a cold vest as compared with controls (no cold vest) on cardiovascular risk factors such as blood lipids, insulin, blood pressure and body weight and also on basal metabolic rate. Recruitment of 100 participants and 70 are randomized to being given a vest which they can use to increase basal metabolic rate during 1-2 hours (as long as the pre-cooled vest stays cool) by activating brown adipose tissue and/or shivering. The remaining 30 subjects will constitute a control group. Lab tests and anthropometrics are checked at baseline, after 2 months and after 1 year.
Interventions
OTHERcold vest
The lowering of body temperature increases basal metabolic rate
Sponsors
University Hospital, Linkoeping
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
* healthy subjects that have no known metabolic relevant diseases
Exclusion criteria
* thyroid disease, * mental disorders, * language problems
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| basal metabolic rate | up to 1 year | basal metabolic rate measured in the fasting state by indirect calorimetry |
| Composite measure of cardiovascular risk factors | up to 1 year | Blood lipids, insulin, body weight, blood pressure |
Countries
Sweden
Outcome results
None listed