Tissue Oxygen Index and Pulsatility Index in Orthopedic Surgery: a NIRS and TCD Pilot Trial

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02340416

Enrollment

Registered

2015-01-16

Start date

2014-08-31

Completion date

2016-01-31

Last updated

2016-03-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cerebral Microemboli

Keywords

orthopedic surgeries, general anesthesia

Brief summary

Cerebral microemboli (ME) are frequently generated during major orthopaedic surgery. The primary objective of this study was applying novel transcranial Doppler (TCD) ultrasound software algorithm to quantify (ME load/15 minutes) and qualify (particulate vs. gaseous) ME, detected as high-intensity transient signals (HITS) in both middle cerebral arteries (MCAs) before and after orthopaedic surgery.

Interventions

DEVICETranscranial Doppler Ultrasound, DWL Doppler BoxX

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

50 Years to 90 Years

Healthy volunteers

Inclusion criteria

* hip prosthesis * knee prosthesis * shoulder prosthesis * spine surgery

Exclusion criteria

* severe valvular heart defect * acute neurological disorder

Design outcomes

Primary

Measure	Time frame
Cerebral microemboli detection	prior and directly after surgery

Countries

Austria

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 10, 2026