A Clinical Study of Subclinical Enthesitis and Synovitis in Patients With Vulgaris Psoriasis

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02339636

Enrollment

200

Registered

2015-01-15

Start date

2015-03-31

Completion date

2016-12-31

Last updated

2015-01-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Vulgaris Psoriasis

Keywords

subclinical, enthesitis, synovitis

Brief summary

A clinical study of subclinical enthesitis and synovitis in patients with vulgaris psoriasis

Detailed description

A total of 100 patients with vulgaris psoriasis and 100 age-matched controls with other skin diseases, all without musculoskeletal diseases, will be recruited. They will undergo dermatological assessment and a blinded PDUS evaluation. Clinical assessment included demographics, severity of psoriasis, musculoskeletal clinical examination and sport activities. PDUS evaluation consisted of the detection of grey scale (GS) synovitis and synovial PD signal in joints of extremities, GS enthesopathy and entheseal PD signal in entheses of lower limbs.

Interventions

OTHERPDUS examination

Study design

Observational model

CASE_CONTROL

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* age≥18years * patients with vulgaris psoriasis(dur * patients with other skin diseases without musculoskeletal disorders * no joint involvement and no clinical symptoms and signs of enthesitis and synovitis

Exclusion criteria

* BMI≥24 * have history of gout or arthritis or peripheral neurological disease of lower extremity or trauma * have received any systemic therapy(i.e.NSAIDs, corticosteroids, immunosuppressants, retinoids or biological agents) in 3 months * pregnant or breast-feeding

Design outcomes

Primary

Measure	Time frame	Description
Incidence of subclinical enthesitis and synovitis	one and a half year	To investigate the incidence of subclinical enthesitis and synovitis in patients with vulgaris

Secondary

Measure	Time frame	Description
Number of participants with Risk factors of subclinical enthesitis and synovitis	one and a half year	To find out predictor factors of subclinical enthesitis and synovitis in patients with vulgaris psoriasis

Countries

China

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026