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Study of Heat and Intravenous Fluids for Exogenous Rewarming

Study of Heat and Intravenous Fluids for Exogenous Rewarming (SHIVER)

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT02339103
Acronym
SHIVER
Enrollment
8
Registered
2015-01-15
Start date
2015-01-31
Completion date
2015-07-31
Last updated
2018-11-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypothermia

Keywords

arteriovenous anastomoses, accidental hypothermia, rewarming

Brief summary

The purpose of this study is to compare two novel active rewarming techniques in mildly hypothermic people. Volunteers will undergo 3 cooling trials in a circulating bath at 14 degrees celsius and will then be rewarmed with either shivering alone, warmed iv fluids (IVF), or water perfusion pads applied to the hands and feet. The investigators hypothesize that both heated IVF and water perfusion pads to the arteriovenous anastomoses (AVAs) will prove to provide significantly superior rewarming rates than shivering alone.

Interventions

OTHERWarmed IV fluids

1 Liter of warmed IV fluids at 42 degrees celsius

OTHERWarmed perfusion pads

Neoprene perfusion pads placed on the palms and soles to rewarm through focusing on the arteriovenous anastomoses

Sponsors

Stanford University
Lead SponsorOTHER

Study design

Allocation
NON_RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes

Inclusion criteria

* Any healthy male or female over 18 years of age

Exclusion criteria

* No heart/blood pressure/cholesterol medications. * No history of Raynaud's disease or any other condition (including asthma) that could be aggravated by cold-water immersion

Design outcomes

Primary

MeasureTime frameDescription
Rate of rewarming60 minutesTrack to rate of rewarming of each arm

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026