Nerveblocks for Persistent Pain After Breast Cancer Surgery

Tenderpoint and Ultrasound Guided Nerveblocks for Persistent Pain After Breast Cancer Surgery

Status

UNKNOWN

Phases

Phase 3

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02336529

Enrollment

Registered

2015-01-13

Start date

2016-07-31

Completion date

2017-07-31

Last updated

2015-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Breast Cancer, Neuropathic Pain, Pain

Keywords

postoperative

Brief summary

Persistent pain after breast cancer surgery (PPBCS) affects 25-60% of breast cancer survivors and nerve damage has been implicated as the cause of this neuropathic pain condition. Local anaesthetic blockade of tenderpoints and the intercostobrachial nerve (ICBN) could provide clues to pathophysiological mechanisms as well as aiding diagnosis and treatment of PPBCS but has never been attempted. The aims of this study is to examine clinical effect of ultrasound guided blockades of the ICBN and tenderpoints of pain.

Interventions

DRUGBupivacaine

DRUGNaCl

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

DIAGNOSTIC

Masking

TRIPLE (Subject, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

FEMALE

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* At least 1 year after surgery for breast cancer * Women aged 18 or over * Suffering from persistent pain in the breast, side of chest, axilla or arm (NRS 4 or over)

Exclusion criteria

* Previous cosmetic surgery * bilateral cancer * pregnant or lactating * other disease in the nervous system * in treatment for psychiatric disease * unable to understand Danish * unable to give informed concent

Design outcomes

Primary

Measure	Time frame	Description
Summed pain intensity	At least 1 year after surgery	The summed pain intensity (of pain at rest (0-10), pain during movement (0-10) and pressure pain (at 100kPa in point of maximum pain) (0-10)) 0-30

Secondary

Measure	Time frame	Description
Pain at rest, pain during movement and pressure pain	At least 1 year after surgery	Pain intensity of pain at rest (0-10), pain during movement (0-10) and pressure pain (at 100kPa in point of maximum pain) (0-10)
Pain related reduction of physical function	At least 1 year after surgery	Reduction of physical function

Contacts

Primary ContactNelun Wijayasinghe, MD

nelun.wijayasinghe@regionh.dk+4535454496

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026