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Impact of Dyspnea on Patients in the Intensive Care Unit

Impact of DYSpnea on the ouTcome of Patients Admitted for an Acute RESpiratory Failure in the intenSive Care Unit

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT02336464
Acronym
DYSTRESS
Enrollment
624
Registered
2015-01-13
Start date
2016-01-31
Completion date
2018-06-30
Last updated
2021-03-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dyspnea

Brief summary

Although pain has been extensively studied in ICU patients, only a few studies have focused on dyspnea, which is experienced by 50% of mechanically ventilated patients. The purpose of the present study is to determine whether dyspnea in intensive care unit patients is associated with a higher length of stay in the ICU and a higher incidence of post traumatic stress disorders.

Detailed description

Intensive care unit (ICU) patients are continuously exposed to various unpleasant sensations that are as many sources of discomfort. If, growing attention has been given to the detection and treatment of pain, very little attention has been given to dyspnea. However, there is growing evidence suggesting that dyspnea is frequent and severe in mechanically ventilated ICU patients. In mechanically ventilated ICU patients, dyspnea is independently associated with anxiety and mechanical ventilation itself. Indeed, an optimization of ventilator settings alleviates dyspnea in 35% of patients. Various arguments suggest that dyspnea contributes to the dark experience of ICU and participates to the genesis of post traumatic stress disorders. In addition, dyspnea is associated with a longer duration of mechanical ventilation. Large multicentre studies are however lacking. The aims of the present multicentre study are 1) to quantify the prevalence of dyspnea in a large population of ICU mechanically ventilated patients, 2) to examine the link between the level of dyspnea and the occurrence of adverse events in the ICU, 3) to determine whether dyspnea in intensive care unit patients is associated with a higher length of stay in the ICU and a higher incidence of post traumatic stress disorder associated symptoms.

Interventions

None listed

Sponsors

Assistance Publique - Hôpitaux de Paris
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* Invasive mechanical ventilation in the ICU for \> 24 hours * Remaining stay in the ICU estimated \> 24 hours

Exclusion criteria

: * RASS \<-2 or \>+2 * Delirium (defined according to CAM-ICU) * Severe cognitive impairment or severe psychiatric disease * Patient who does not understand French * Severe depthless * Age \<18 years

Design outcomes

Primary

MeasureTime frame
ICU length of stay3 months
incidence of post traumatic stress disorders3 months

Secondary

MeasureTime frameDescription
Anxiety and depression (Hamilton anxiety and depression scale)3 monthsHamilton anxiety and depression scale
Quality of life (Short-Form 36)3 monthsShort-Form 36
Pain (Visual Analogic Scale)3 monthsVisual Analogic Scale
Quality of Sleep (Pittsburgh Scale)3 monthsPittsburgh Scale

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 13, 2026