Overactive Bladder
Conditions
Keywords
urinary bladder, nerve growth factor, overactive bladder
Brief summary
Nerve growth factor (NGF-R) receptors are between the detrusor muscle fibers and can cause afferent signals. Metabolic syndrome and obesity have been advocated to be risk factors for the development of overactive bladder.
Detailed description
Overactive bladder is a clinical syndrome characterized urgency, frequency and nocturia. Infection or other obvious causes must be excluded. The overactive bladder is loss of inhibition of the detrusor muscle during the filling or emptying of the bladder. Specific receptors and neurotransmitters have role in development of overactive bladder. These includes adrenergic, cholinergic, non-adrenergic, non-cholinergic receptors and interstitial cells. Nerve growth factor (NGF-R) receptors are between the detrusor muscle fibers and can cause afferent signals. Metabolic syndrome and obesity have been advocated to be risk factors for the development of overactive bladder. The investigators believe that our findings will shed light on treatment.
Interventions
None listed
Sponsors
Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Study design
Observational model
CASE_ONLY
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* women with urgency, nocturia and frequency * Abdominal obesity, defined as a waist circumference in men ≥88 cm * Serum triglycerides ≥150 mg/dL (1.7 mmol/L) or drug treatment for elevated triglycerides * Serum HDL cholesterol \<40 mg/dL (1 mmol/L) in men and \<50 mg/dL (1.3 mmol/L) in women or drug treatment for low HDL-C * Blood pressure ≥130/85 mmHg or drug treatment for elevated blood pressure * Fasting plasma glucose (FPG) ≥100 mg/dL (5.6 mmol/L) or drug treatment for elevated blood glucose
Exclusion criteria
* Chronic obstructive pulmonary disease allergy * Psychiatric disorders * Urinary tract infection * Neurological diseases * Metabolic diseases * Pure stress or mixed urinary incontinence * History of pelvic surgery * Diabetes mellitus
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| nerve growth factor levels | 3 months | association between nerve growth factor levels and overactive bladder |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| urge incontinence | 3 months | number of urge incontinence |
| overactive bladder symptoms | 3 months | number of nocturia,urgency,frequency |
Countries
Turkey (Türkiye)
Outcome results
None listed