Endometrial Cancer
Conditions
Brief summary
The purposes of this study are to determine whether total lymph node count or the percentage of identified nodes with metastatic disease are influenced by (1) the method of categorizing tissue specimens or (2) the techniques of pathologic processing following lymphadenectomy. Patients with newly diagnosed endometrial carcinoma of high risk histologic type or uterine carcinosarcoma whose risk of LN metastasis exceeds 15% will be enrolled on this study. Patients will undergo staging to include hysterectomy and selective lymphadenectomy as per the clinical judgment of the primary Gynecologic Oncologist. Type of hysterectomy and the extent and distribution of lymphadenectomy is at the discretion of the surgeon. All patients will be scheduled for surgical staging. Each subject will have lymph nodes harvested on one side divided into specific basins, and on the contralateral side classified only as pelvic or aortic. Surgical node specimens in the operating room will be labeled by (1) specific nodal basins on the randomly determined side as external iliac, obturator, common iliac, aortic, or high aortic and by (2) pelvic versus aortic (common iliac nodes will be considered as part of the pelvic specimen) on the contralateral side.
Interventions
None listed
Sponsors
Duke University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Healthy volunteers
No
Inclusion criteria
* Uterine cancer with one of the following pathologies: serous, clear cell, sarcoma or grade 3 differentiation * surgical candidate
Exclusion criteria
\-
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total gross node identification | 0-14 days post op |
| Percentage of lymph nodes showing metastatic cancer (%NM) | 0-14 days post op |
Countries
United States
Outcome results
None listed