Liver Cirrhosis
Conditions
Keywords
Prognosis
Brief summary
Liver biopsy is the reference method for the measurement of liver fibrosis. But it has many limitations, such as sampling error and individual variation in interpreting the results. Currently, serum liver fibrosis markers have been employed as non-invasive diagnosis of liver fibrosis and evaluation of the severity of liver fibrosis. They include laminin (LN), hyaluronic acid (HA), collagen type IV (CIV), and N-terminal propeptide of collagen III (PIIINP). However, few study was conducted to explore the role of these liver fibrosis markers in evaluating the prognosis of liver cirrhosis. Our hypothesis is that LN, HA, CIV, and PIIINP in combination or alone can predict the prognosis of liver cirrhosis.
Interventions
OTHERVenous blood
Sponsors
General Hospital of Shenyang Military Region
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
1. Patients were admitted to our department. 2. Patients were diagnosed with liver cirrhosis. 3. Patients signed the informed consent and agreed to test serum liver fibrosis markers (PIIINP, CIV, LN, and HA).
Exclusion criteria
1. Non-cirrhotic patients. 2. Malignancy. 3. Severe cardiopulmonary diseases. 4. Severe infectious diseases. 5. Other diseases with a shortened lifespan. 6. Pregnant and breastfeeding. 7. Poor adherence.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Death | 6-12 months |
Secondary
| Measure | Time frame |
|---|---|
| Hepatic decompensation events | 6-12 months |
Countries
China
Outcome results
None listed